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Electrophysiological Correlates of Information Processing in Breast-Cancer Patients Treated With Adjuvant Chemotherapy

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Summary

Cognitive deficits are found in a number of breast-cancer patients who have undergone adjuvant (Cyclophosphamide, Methotrexate, and 5-Fluorouracil (CMF)) chemotherapy, but the underlying mechanisms are still unclear. The objective of this study is to investigate information processing in these patients with concurrent registration of brain activity.

Twenty-six breast-cancer patients treated with adjuvant CMF chemotherapy and a control group of 23 stage I breast-cancer patients not treated with chemotherapy were examined. Mean time since treatment for the CMF patients was 5.1 years after the last CMF course, and for the control patients 3.6 years after termination of radiotherapy. An information processing task was administered with concurrent EEG registration. Reaction times and the amplitudes and latencies of an Event Related Potential component (P3) in different task conditions related to input, central, and output processing of information were studied.

Significant differences in latency and amplitude of the P3 component were found between the treatment groups with an earlier and reduced P3 in the chemotherapy group. Patients treated with chemotherapy had longer reaction times (although not significantly different) than the control group on all task conditions.

Our data provide further evidence for long-term neurocognitive problems in breast-cancer patients treated with adjuvant (CMF) chemotherapy and offer new information regarding abnormalities in brain functioning in these patients.

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References

  1. TA Ahles AJ Saykin CT Furstenberg B Cole LA Mott K Skalla MB Whedon S Bivens T Mitchell ER Greenberg PM Silberfarb (2002) ArticleTitleNeuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma J Clin Oncol 20 485–493 Occurrence Handle10.1200/JCO.20.2.485 Occurrence Handle11786578 Occurrence Handle1:CAS:528:DC%2BD38XovVKhsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  2. CB Brezden KA Phillips M Abdolell T Bunston IF Tannock (2000) ArticleTitleCognitive function in breast cancer patients receiving adjuvant chemotherapy J Clin Oncol 18 2695–2701 Occurrence Handle10894868 Occurrence Handle1:CAS:528:DC%2BD3cXls12iu7w%3D

    PubMed  CAS  Google Scholar 

  3. A Minisini G Atalay A Bottomley F Puglisi M Piccart L Biganzoli (2004) ArticleTitleWhat is the effect of systemic anticancer treatment on cognitive function? Lancet Oncol 5 273–282 Occurrence Handle10.1016/S1470-2045(04)01465-2 Occurrence Handle15120664

    Article  PubMed  Google Scholar 

  4. SB Schagen FS Dam Particlevan MJ Muller W Boogerd J Lindeboom PF Bruning (1999) ArticleTitleCognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma Cancer 85 640–650 Occurrence Handle10.1002/(SICI)1097-0142(19990201)85:3<640::AID-CNCR14>3.0.CO;2-G Occurrence Handle10091737 Occurrence Handle1:STN:280:DyaK1M7ptVWmug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  5. FS Dam ParticleVan SB Schagen MJ Muller W Boogerd E vd Wall ME Droogleever Fortuyn S Rodenhuis (1998) ArticleTitleImpairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy J Natl Cancer Inst 90 210–218 Occurrence Handle10.1093/jnci/90.3.210 Occurrence Handle9462678

    Article  PubMed  Google Scholar 

  6. JS Wefel R Lenzi RL Theriault RN Davis CA Meyers (2004) ArticleTitleThe cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial Cancer 100 2292–2299 Occurrence Handle10.1002/cncr.20272 Occurrence Handle15160331 Occurrence Handle1:CAS:528:DC%2BD2cXltFWqu7g%3D

    Article  PubMed  CAS  Google Scholar 

  7. E Chu A Mota M Fogarasi (2001) Antimetabolites (Section 5). Pharmacology of cancer chemotherapy (Chapter 19) VT DeVita S Hellman SA Rosenberg (Eds) Cancer. Principles & Practice of Oncology Lippincott Williams & Wilkins Philadelphia 388–415

    Google Scholar 

  8. MK Tuxen SW Hansen (1994) ArticleTitleNeurotoxicity secondary to antineoplastic drugs Cancer Treat Rev 20 191–214 Occurrence Handle10.1016/0305-7372(94)90027-2 Occurrence Handle8156541 Occurrence Handle1:CAS:528:DyaK2cXlsVyis7s%3D

    Article  PubMed  CAS  Google Scholar 

  9. AJ Saykin TA Ahles BC McDonald (2003) ArticleTitleMechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectives Semin Clin Neuropsychiatr 8 201–216

    Google Scholar 

  10. SB Schagen HL Hamburger MJ Muller W Boogerd FS Dam ParticleVan (2001) ArticleTitleNeurophysiological evaluation of late effects of adjuvant high-dose chemotherapy on cognitive function J Neurooncol 51 159–165 Occurrence Handle10.1023/A:1010635229762 Occurrence Handle11386413 Occurrence Handle1:STN:280:DC%2BD3MzhtlGrtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  11. EJ Jonkman AC Huffelen Particlevan G Pfurtscheller (1986) Quantitative EEG and cerebral ischemia FH Lopes da Silva W Storm van Leeuwen A Remond (Eds) Handbook of Electroencephalography and Clinical Neurophysiology Elsevier Amsterdam 205–237

    Google Scholar 

  12. R Halliday H Naylor D Brandeis E Callaway L Yano K Herzig (1994) ArticleTitleThe effect of D-amphetamine, clonidine, and yohimbine on human information processing Psychophysiology 31 331–337 Occurrence Handle10690913 Occurrence Handle1:STN:280:DC%2BD3c7lt1OksA%3D%3D

    PubMed  CAS  Google Scholar 

  13. J Ruijter MB Ruiter Particlede J Snel MM Lorist (2000) ArticleTitleThe influence of caffeine on spatial-selective attention: an event-related potential study Clin Neurophysiol 111 2223–2233 Occurrence Handle10.1016/S1388-2457(00)00462-4 Occurrence Handle11090776 Occurrence Handle1:CAS:528:DC%2BD3MXis1WmtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  14. FT Smulders JL Kenemans WF Schmidt A Kok (1999) ArticleTitleEffects of task complexity in young and old adults: reaction time and P300 latency are not always dissociated Psychophysiology 36 118–125 Occurrence Handle10.1017/S0048577299961590 Occurrence Handle10098387 Occurrence Handle1:STN:280:DyaK1M7pvVClsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  15. MW Molen ParticleVan der TR Bashore R Halliday E Callaway (1991) Chronopsychophysiology: mental chronometry augmented by psychophysiological time markers JR Jennings MGH Coles (Eds) Handbook of Cognitive Psychophysiology: Central and Autonomic Nervous System Approaches John Wiley & Sons Ltd Chichester 9–178

    Google Scholar 

  16. E Donchin MGH Coles (1988) ArticleTitleIs the P300 component a manifestation of context updating Behav Brain Sci 11 357–374 Occurrence Handle10.1017/S0140525X00058027

    Article  Google Scholar 

  17. R. Johnson ParticleJr. (1988) ArticleTitleThe amplitude of the P300 component of the event-related potential: review and synthesis Adv psychophysiol 3 69–137

    Google Scholar 

  18. A Kok (2001) ArticleTitleOn the utility of P3 amplitude as a measure of processing capacity Psychophysiology 38 557–577 Occurrence Handle10.1017/S0048577201990559 Occurrence Handle11352145 Occurrence Handle1:STN:280:DC%2BD3M3lsVaksA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  19. RJ Barry SJ Johnstone AR Clarke (2003) ArticleTitleA review of electrophysiology in attention-deficit/hyperactivity disorder: II. Event-related potentials Clin Neurophysiol 114 184–198 Occurrence Handle10.1016/S1388-2457(02)00363-2 Occurrence Handle12559225

    Article  PubMed  Google Scholar 

  20. O Stelt Particlevan der J Frye JA Lieberman A Belger (2004) ArticleTitleImpaired P3 generation reflects high-level and progressive neurocognitive dysfunction in schizophrenia Arch Gen Psychiatr 61 237–248 Occurrence Handle10.1001/archpsyc.61.3.237 Occurrence Handle14993111

    Article  PubMed  Google Scholar 

  21. H Saito H Yamazaki H Matsuoka K Matsumoto Y Numachi S Yoshida T Ueno M Sato (2001) ArticleTitleVisual event-related potential in mild dementia of the Alzheimer’s type Psychiatr Clin Neurosci 55 365–371 Occurrence Handle10.1046/j.1440-1819.2001.00876.x Occurrence Handle1:STN:280:DC%2BD3Mvos1aquw%3D%3D

    Article  CAS  Google Scholar 

  22. S Sternberg (1969) ArticleTitleThe discovery of processing stages: extensions of Donders’ method Acta Psychol 30 276–315 Occurrence Handle10.1016/0001-6918(69)90055-9

    Article  Google Scholar 

  23. AF Sanders (1983) ArticleTitleTowards a model of stress and human performance Acta Psychol (Amst) 53 61–97 Occurrence Handle10.1016/0001-6918(83)90016-1 Occurrence Handle1:STN:280:DyaL3s3lt1ektw%3D%3D

    Article  CAS  Google Scholar 

  24. AF Sanders (1990) ArticleTitleIssues and trends in the debate on dicrete vs. continuous processing of information Acta Psychol 74 123–167 Occurrence Handle10.1016/0001-6918(90)90004-Y

    Article  Google Scholar 

  25. A Kok (1997) ArticleTitleEvent-related-potential (ERP) reflections of mental resources: a review and synthesis Biol Psychol 45 19–56 Occurrence Handle10.1016/S0301-0511(96)05221-0 Occurrence Handle9083643 Occurrence Handle1:STN:280:DyaK2s3jslWltw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  26. LR Derogatis RS Lipman K Rickels EH Uhlenhuth L Covi (1974) ArticleTitleThe Hopkins Symptom Checklist (HSCL). A measure of primary symptom dimensions Mod Probl Pharmacopsychiatr 7 79–110 Occurrence Handle1:STN:280:DyaE2M%2Fhs1yitQ%3D%3D

    CAS  Google Scholar 

  27. PT Hesbacher K Rickels RJ Morris H Newman H Rosenfeld (1980) ArticleTitlePsychiatric illness in family practice J Clin Psychiatr 41 6–10 Occurrence Handle1:STN:280:DyaL3c%2FpsVemsw%3D%3D

    CAS  Google Scholar 

  28. RL Hough JA Landsverk GF Jacobsen (1990) The use of psychiatric screening scales to detect depression in primary care patients CC Attkinsson JM Zich (Eds) Depression in Primary Care: Screening and Detection Routledge New York & London

    Google Scholar 

  29. FDM Wald GJ Mellenbergh (1990) ArticleTitleDe verkorte versie van de Nederlandse vertaling van de Profile of Mood States (POMS) Nederlands Tijdschrift voor de Psychologie 45 86–90

    Google Scholar 

  30. WF Regine FA Schmitt CB Scott C Dearth RA Patchell RC Nichols SuffixJr. EM Gore RL Franklin ParticleIII JH Suh MP Mehta (2004) ArticleTitleFeasibility of neurocognitive outcome evaluations in patients with brain metastases in a multi-institutional cooperative group setting: results of Radiation Therapy Oncology Group trial BR-0018 Int J Radiat Oncol Biol Phys 58 1346–1352 Occurrence Handle10.1016/j.ijrobp.2003.09.023 Occurrence Handle15050309

    Article  PubMed  Google Scholar 

  31. N Jong Particlede MJ Candel HC Schouten HH Abu-Saad AM Courtens (2004) ArticleTitlePrevalence and course of fatigue in breast cancer patients receiving adjuvant chemotherapy Ann Oncol 15 896–905 Occurrence Handle10.1093/annonc/mdh229 Occurrence Handle15151946

    Article  PubMed  Google Scholar 

  32. EMA Smets B Garssen B Bonke (1995) Het meten van vermoeidheid met de Multidimensionele Vermoeidheids Index (MVI-20): Een handleiding Medische Psychologie, Academisch Medisch Centrum Amsterdam, The Netherlands

    Google Scholar 

  33. E Donchin (1981) ArticleTitleSurprise! Surprise? Psychophysiology 18 493–513 Occurrence Handle7280146 Occurrence Handle1:STN:280:DyaL38%2Fhs1Sqtw%3D%3D

    PubMed  CAS  Google Scholar 

  34. CW Berridge BD Waterhouse (2003) ArticleTitleThe locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes Brain Res Brain Res Rev 42 33–84 Occurrence Handle10.1016/S0165-0173(03)00143-7 Occurrence Handle12668290

    Article  PubMed  Google Scholar 

  35. Nieuwenhuis S, Aston-Jones G, Cohen JD: Decision making, the P3, and the Locus Coeruleus-Norepinephrine System. Psychol Bull, in press

  36. J Keller BD Hicks GA Miller (2000) Psychophysiology in the study of psychopathology JT Cacioppo LG Tassinary GG Berntson (Eds) Handbook of Psychophysiology NumberInSeries2 Cambridge University Press Cambridge 719–750

    Google Scholar 

  37. SB Schagen MJ Muller W Boogerd FS Dam ParticleVan (2002) ArticleTitleCognitive dysfunction and chemotherapy: neuropsychological findings in perspective Clin Breast Cancer 3 IssueIDSuppl 3 S100–S108 Occurrence Handle12533270 Occurrence Handle10.3816/CBC.2002.s.020

    Article  PubMed  Google Scholar 

  38. Boogerd W: Neurological complications of chemotherapy. In: Vinken and Bruyn (ed) Handbook of Clinical Neurology: Intoxications of the Nervous System Part II. Elsevier Science, 1995, pp 527–546

  39. WA Bleyer (1981) ArticleTitleNeurologic sequelae of methotrexate and ionizing radiation: a new classification Cancer Treat Rep 65 IssueIDSuppl 1 89–98 Occurrence Handle6948611

    PubMed  Google Scholar 

  40. A Paganini-Hill LJ Clark (2000) ArticleTitlePreliminary assessment of cognitive function in breast cancer patients treated with tamoxifen Breast Cancer Res Treat 64 165–176 Occurrence Handle10.1023/A:1006426132338 Occurrence Handle11194452 Occurrence Handle1:CAS:528:DC%2BD3MXlt1Gnuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  41. SA Castellon PA Ganz JE Bower L Petersen L Abraham GA Greendale (2004) ArticleTitleNeurocognitive performance in breast cancer survivors exposed to adjuvant chemotherapy and tamoxifen J Clin Exp Neuropsychol 26 955–969 Occurrence Handle15742545

    PubMed  Google Scholar 

  42. JL Eberling C Wu R Tong-Turnbeaugh WJ Jagust (2004) ArticleTitleEstrogen- and tamoxifen-associated effects on brain structure and function Neuroimage 21 364–371 Occurrence Handle10.1016/j.neuroimage.2003.08.037 Occurrence Handle14741674

    Article  PubMed  Google Scholar 

  43. T Ernst L Chang D Cooray C Salvador J Jovicich I Walot K Boone R Chlebowski (2002) ArticleTitleThe effects of tamoxifen and estrogen on brain metabolism in elderly women J Natl Cancer Inst 94 592–597 Occurrence Handle11959892 Occurrence Handle1:CAS:528:DC%2BD38Xjs1Kju7o%3D

    PubMed  CAS  Google Scholar 

  44. C Falo A Moreno E Benito B Lloveras M Varela JM Serra L Prieto D Azpeitia A Escobedo (2005) ArticleTitlePrimary chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil in operable breast carcinoma Cancer 103 657–663 Occurrence Handle10.1002/cncr.20829 Occurrence Handle15648085 Occurrence Handle1:CAS:528:DC%2BD2MXit1Ghu7k%3D

    Article  PubMed  CAS  Google Scholar 

  45. SB Schagen MJ Muller W Boogerd RM Rosenbrand D Rhijn Particlevan S Rodenhuis FS Dam ParticleVan (2002) ArticleTitleLate effects of adjuvant chemotherapy on cognitive function: a follow-up study in breast cancer patients Ann Oncol 13 1387–1397 Occurrence Handle10.1093/annonc/mdf241 Occurrence Handle12196364 Occurrence Handle1:STN:280:DC%2BD38vjvVGjtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Baudewijntje P. C. Kreukels, Sanne B. Schagen & Frits S. A. M. van Dam

  2. Department of Medical Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Willem Boogerd

  3. Department of Psychology, University of Amsterdam, The Netherlands

    K. Richard Ridderinkhof & Frits S. A. M. van Dam

  4. Department of Neurology, Slotervaart Hospital, Amsterdam, The Netherlands

    Willem Boogerd & Hans L. Hamburger

  5. Department of Clinical Neurophysiology, Slotervaart Hospital, Amsterdam, The Netherlands

    Hans L. Hamburger

  6. Department of Psychology, Leiden University, The Netherlands

    K. Richard Ridderinkhof

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  1. Baudewijntje P. C. Kreukels
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  2. Sanne B. Schagen
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  3. K. Richard Ridderinkhof
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  4. Willem Boogerd
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  6. Frits S. A. M. van Dam
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Correspondence to Baudewijntje P. C. Kreukels.

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Kreukels, B.P.C., Schagen, S.B., Ridderinkhof, K.R. et al. Electrophysiological Correlates of Information Processing in Breast-Cancer Patients Treated With Adjuvant Chemotherapy. Breast Cancer Res Treat 94, 53–61 (2005). https://doi.org/10.1007/s10549-005-7093-3

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