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Cortical Signature of Neurological Soft Signs in Recent Onset Schizophrenia

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Abstract

Motor symptoms such as neurological soft signs (NSS) are characteristic phenomena of schizophrenia at any stage of the illness. Neuroimaging studies in schizophrenia patients have shown regional thinning of the cortical mantle, but it is unknown at present whether NSS are related to cortical thickness changes. Whole brain high-resolution magnetic resonance imaging at 3 Tesla was used to investigate cortical thickness in 28 patients with recent-onset schizophrenia. Cortical reconstruction was performed with the Freesurfer image analysis suite. NSS were examined on the Heidelberg Scale and related to cortical thickness. Age, education, and medication were considered as potential confounders. Higher NSS scores were associated with morphological changes of cortical thickness in multiple areas comprising paracentral gyrus, postcentral lobule, precuneus, inferior parietal lobule and temporal lobe. Our results confirm the hypothesis of a significant relationship between cortical thickness changes and the extent of NSS in schizophrenia. Investigation of cortical thickness may help to explain subtle motor symptoms such as NSS in schizophrenia.

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Acknowledgments

The authors cordially thank all patients for participating in this study.

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Authors and Affiliations

  1. Structural Neuroimaging Group, Department of General Psychiatry, University of Heidelberg, Voßstraße 4, 69115, Heidelberg, Germany

    Dusan Hirjak & Philipp Arthur Thomann

  2. Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany

    Dusan Hirjak, Robert Christian Wolf & Philipp Arthur Thomann

  3. Section Quantitative Imaging Based Disease Characterization, Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Bram Stieltjes

  4. Department of Radiology (E010), German Cancer Research Center (DKFZ), Heidelberg, Germany

    Thomas Hauser

  5. Center for Mental Health, Klinikum Stuttgart, Stuttgart, Germany

    Ulrich Seidl

  6. Section of Geriatric Psychiatry, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany

    Johannes Schröder

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  1. Dusan Hirjak
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  2. Robert Christian Wolf
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  3. Bram Stieltjes
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Correspondence to Dusan Hirjak.

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Hirjak, D., Wolf, R.C., Stieltjes, B. et al. Cortical Signature of Neurological Soft Signs in Recent Onset Schizophrenia. Brain Topogr 27, 296–306 (2014). https://doi.org/10.1007/s10548-013-0292-z

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