Abstract
The aims of the study were to assess the effectiveness of enzyme replacement therapy (ERT) with laronidase on the range of motion (ROM) of upper extremities and influence on activities of daily living (ADLs) of patients with mucopolysaccharidosis type I (MPS I). The ROM of 17 patients with MPS I was followed from the first year of life until the introduction of ERT and after 52–208 weeks of treatment. In all patients (group 1, n = 10), passive ROM was assessed. In patients with Hurler/Scheie or Scheie phenotype (group 2, n = 7) both passive and active ROM, as well as daily life activities, were evaluated. Passive and active ROM was measured by a goniometer, while a health assessment questionnaire was used to assess activities of daily living. The data since the first months of life until the beginning of treatment were obtained by retrospective review of patients’ charts. Restriction in ROM of the upper extremities of patients with MPS I was observed from the first year of life. These limitations intensified and became more severe with the patients’ age, making patients’ self-care more difficult or even impossible. Introduction of ERT led to slower progression of symptoms, especially in the passive range of motion in all patients. Additionally, patients with normal mental development, or only slightly delayed (group 2), who underwent active physical rehabilitation (including mobilisation of nerve system, passive techniques for joint mobility, active gymnastics for muscle power, as well as massage and the training of families for therapy at home) showed improvement in active movement followed by enhanced self-care.
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Abbreviations
- ADL:
-
activities of daily living
- AE:
-
adverse event
- GAG:
-
glycosaminoglycan
- ERT:
-
enzyme replacement therapy
- HAQ:
-
health assessment questionnaire
- IDUA:
-
α-L-iduronidase
- MPS:
-
mucopolysaccharidosis
- PT:
-
physical therapy
- ROM:
-
range of motion
- SFTR:
-
sagittal, frontal, transverse rotation system
References
Backup K (1995) Klinische Tests an Knochen Geleken und Muskeln, vol. 4. Georg Thieme, Stuttgart
Clarke L, Wraith E, Beck M et al (2009) Long-term efficacy and safety of laronidase in the treatment of mucopolysaccharidosis I. Pediatrics 123:229–240
Cox-Brinkman J, Smeulders MJ, Hollak CE, Wijburg FA (2007) Restricted upper extremity range of motion in mucopolysaccharidosis type I: no response to one year of enzyme replacement therapy. J Inherit Metab Dis 30:47–50
Doorenbosh CA, Harlaar J, Veeger D (2003) The globe system: an unambiguous description of shoulder positions in daily life movements. J Rehabil Res Dev 40:147–156
Gerhardt JJ, Rondinelli RD (2001) Goniometric techniques for range-of-motion assessment. Phys Med Rehabil Clin N Am 12:507–527
Hinek A, Wilson S (2000) Impaired elastogenesis in Hurler disease: dermatan sulfate accumulation linked to deficiency in elastin-binding protein and elastic fiber assembly. Am J Pathol 156:925–938
Kakkis ED, Muenzer J, Tiller GE et al (2001) Enzyme replacement therapy in mucopolysaccharidosis I. N Engl J Med 344:182–188
Neufeld EF, Muenzer J (2001) In: Scriver CR, Beaudet AL, Sly WS, et al (eds) The metabolic and molecular bases of inherited disease. McGraw-Hill, New York, pp. 3421–3452
Norato DYJ, Giovanetti DF (2006) MPS I Registry health assessment questionnaire. In: Abstract book, 9th International Symposium on Mucopolysaccharidosis and Related Diseases, 29 June - 2 July Venice 2006, p. 216
O’Sullivan SB, Schmitz TJ (eds) (1994) Physical rehabilitation: assessment and treatment. 3rd ed, Philadelphia, FA Davis, pp. 146–152.
Pastores GM, Meere PA (2005) Musculoskeletal complications associated with lysosomal storage disorders: Gaucher disease and Hurler-Scheie syndrome (mucopolysaccharidosis type I). Curr Opin Rheum 17:70–78
Sifuentes M, Doroshow R, Hoft R et al (2007) A follow-up study of MPS I patients treated with laronidase enzyme replacement therapy for 6 years. Mol Genet Metab 90:171–180
Simonaro CM, Haskins ME, Schuchman EH (2001) Articular chondrocytes from animals with a dermatan sulfatase storage disease undergo a high rate of apoptosis and release nitric oxide and inflammatory cytokines: a possible mechanism underlying degenerative joint disease in the mucopolysaccharidoses. Lab Invest 8:1319–1328
Simonaro CM, D’Angelo M, He X, Eliyahu E, Shtraizent N, Haskins ME, Schuchman EH (2008) Mechanism of glycosaminoglycan-mediated bone and joint disease. Am J Pathol 172:112–122
Wraith JE (2001) Advances in the treatment of lysosomal storage disease. Dev Med Child Neurol 43:639–646
Wraith JE, Clarke LA, Beck M et al (2004) Enzyme replacement therapy for mucopolysaccharidosis I: a randomized, double-blinded, placebo-controlled, multinational study of recombinant human alpha-L-iduronidase (laronidase). J Pediatr 144:581–588
Wraith JE, Beck M, Lane R et al (2007) Enzyme replacement therapy in patients who have mucopolysaccharidosis I and are younger than 5 years: results of a multinational study of recombinant human alpha-L-iduronidase( laronidase). Pediatrics 120:e37–e46
Zembaty A (2002) Kinezyterapia. Kraków 68–73:239–243
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Communicated by: Ed Wraith
Reference to electronic databases: α-L-iduronidase: EC 3.2.1.76. Hurler syndrome: OMIM 607016. Hurler–Scheie syndrome: OMIM 607015. Scheie syndrome: OMIM 607016.
Competing interest: None declared.
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Tylki-Szymanska, A., Marucha, J., Jurecka, A. et al. Efficacy of recombinant human α-L-iduronidase (laronidase) on restricted range of motion of upper extremities in mucopolysaccharidosis type I patients. J Inherit Metab Dis 33, 151–157 (2010). https://doi.org/10.1007/s10545-010-9059-9
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DOI: https://doi.org/10.1007/s10545-010-9059-9