Summary
Mitochondria and peroxisomes are ubiquitous subcellular organelles, which fulfil an indispensable role in the cellular metabolism of higher eukaryotes. Moreover, they are highly dynamic and display large plasticity. There is growing evidence now that both organelles exhibit a closer interrelationship than previously appreciated. This connection includes metabolic cooperations and cross-talk, a novel putative mitochondria-to-peroxisome vesicular trafficking pathway, as well as an overlap in key components of their fission machinery. Thus, peroxisomal alterations in metabolism, biogenesis, dynamics and proliferation can potentially influence mitochondrial functions, and vice versa. In this review, we present the latest progress in the emerging field of peroxisomal and mitochondrial interrelationship with a particular emphasis on organelle dynamics and its implication in diseases.
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Abbreviations
- DLP:
-
dynamin-like protein
- ER:
-
endoplasmic reticulum
- MDV:
-
mitochondria-derived vesicle
- MIM:
-
mitochondrial inner membrane
- MOM:
-
mitochondrial outer membrane
- MOMP:
-
mitochondrial outer membrane permeabilization
- mtDNA:
-
mitochondrial DNA
- PBD:
-
peroxisome biogenesis disorder
- PEX:
-
peroxin
- PMP:
-
peroxisomal membrane protein
- PTS:
-
peroxisomal targeting signal
- ROS:
-
reactive oxygen species
- SUMO:
-
small ubiquitin-like modifier
- TA:
-
tail-anchored
- TMD:
-
transmembrane domain
- VLCFA:
-
very long-chain fatty acids
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Acknowledgements
We apologize to those whose work has not been cited owing to space limitations. This work was supported by the German Research Foundation (DFG; SCHR 518/6–1, 2), the Portuguese Foundation for Science and Technology (FCT; PTDC/BIA–BCM/71932/2006, SFRH/BD/37647/2007 to N.A.B.), and the University of Aveiro.
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Camões, F., Bonekamp, N.A., Delille, H.K. et al. Organelle dynamics and dysfunction: A closer link between peroxisomes and mitochondria. J Inherit Metab Dis 32, 163–180 (2009). https://doi.org/10.1007/s10545-008-1018-3
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DOI: https://doi.org/10.1007/s10545-008-1018-3