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Mucopolysaccharidosis I under enzyme replacement therapy with laronidase—A mortality case with autopsy report

  • Case Report
  • Published:
Journal of Inherited Metabolic Disease

Abstract

There is little information about MPS I-related complications during laronidase therapy. We describe the first autopsy report of a young male MPS I patient who died of infection-induced cardiopulmonary failure following 2 years of weekly treatment with laronidase.

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Authors and Affiliations

  1. Department of Pediatrics, Mackay Memorial Hospital, No. 92, Sec. 2, Chung-Shan North Road, Taipei, 10449, Taiwan

    H.-Y. Lin, S.-P. Lin & M.-R. Chen

  2. Departments of Medical Research, Mackay Memorial Hospital, Taipei

    S.-P. Lin & C.-K. Chuang

  3. Departments of Pathology, Mackay Memorial Hospital, Taipei

    B.-F. Chen

  4. Mackay Medicine, Nursing and Management College, Taipei, Taiwan

    S.-P. Lin & M.-R. Chen

  5. College of Medicine, Fu-Jen Catholic University, Taipei, Taiwan

    C.-K. Chuang

  6. Willink Biochemical Genetics Unit, Royal Manchester, Children's Hospital, Manchester, UK

    J. E. Wraith

Authors
  1. H.-Y. Lin
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  2. S.-P. Lin
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  3. C.-K. Chuang
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  4. M.-R. Chen
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  5. B.-F. Chen
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  6. J. E. Wraith
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Corresponding author

Correspondence to S.-P. Lin.

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Lin, HY., Lin, SP., Chuang, CK. et al. Mucopolysaccharidosis I under enzyme replacement therapy with laronidase—A mortality case with autopsy report. J Inherit Metab Dis 28, 1146–1148 (2005). https://doi.org/10.1007/s10545-005-0211-x

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  • DOI: https://doi.org/10.1007/s10545-005-0211-x

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