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Surface acoustic wave induced particle manipulation in a PDMS channel—principle concepts for continuous flow applications

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Abstract

A device for acoustic particle manipulation in the 40 MHz range for continuous-flow operation in a 50 μm wide PDMS channel has been evaluated. Unidirectional interdigital transducers on a Y-cut Z-propagation lithium nixobate wafer were used to excite a surface acoustic wave that generated an acoustic standing wave inside the microfluidic channel. It was shown that particle alignment nodes with different inter-node spacing could be obtained, depending on device design and driving frequency. The observed inter-node spacing differed from the standard half-wavelength inter-node spacing generally employed in bulk acoustic transducer excited resonant systems. This effect and the related issue of acoustic node positions relative the channel walls, which is fundamental for most continuous flow particle manipulation operations in channels, was evaluated in measurements and simulations. Specific applications of particle separation and alignment where these systems can offer benefits relative state-of the art designs were identified.

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Acknowledgments

We would like to acknowledge Prof. Anders Rydberg at Signals and Systems Department Uppsala University for providing the function generator and Dr. Zhigang Wu Material Science Uppsala University for providing the micro beads. Prof. Tamás Pritz at Szikkti Labs Hungary is acknowledged for valuable discussions regarding the frequency dependence of polymer material properties. We also want to thank Prof. Bengt Lundberg at Solid Mechanics Uppsala University for discussions on the dynamic mechanical properties of polymers and Richard O'Leary at the University of Strathclyde Scotland for discussions on measurement methods of sound speed in high-loss materials. None of the persons above have any responsibility for misprints or misunderstandings in the investigation. SSF MS2E and Vinnex VISENET are acknowledged for financial support.

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Authors and Affiliations

  1. Department of Engineering Sciences, Ångström Laboratory, Uppsala University, PO Box 534, SE-75121, Uppsala, Sweden

    Linda Johansson, Johannes Enlund, Stefan Johansson, Ilia Katardjiev & Ventsislav Yantchev

  2. Department of Applied Physics, Albanova/KTH, Roslagsv. 30B, SE-114 19, Stockholm, Sweden

    Linda Johansson

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  1. Linda Johansson
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  2. Johannes Enlund
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  3. Stefan Johansson
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  4. Ilia Katardjiev
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  5. Ventsislav Yantchev
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Correspondence to Linda Johansson.

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Johansson, L., Enlund, J., Johansson, S. et al. Surface acoustic wave induced particle manipulation in a PDMS channel—principle concepts for continuous flow applications. Biomed Microdevices 14, 279–289 (2012). https://doi.org/10.1007/s10544-011-9606-7

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