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Molecular architecture of bacteriophage T4

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Abstract

In studying bacteriophage T4—one of the basic models of molecular biology for several decades—there has come a Renaissance, and this virus is now actively used as object of structural biology. The structures of six proteins of the phage particle have recently been determined at atomic resolution by X-ray crystallography. Three-dimensional reconstruction of the infection device—one of the most complex multiprotein components—has been developed on the basis of cryo-electron microscopy images. The further study of bacteriophage T4 structure will allow a better understanding of the regulation of protein folding, assembly of biological structures, and also mechanisms of functioning of the complex biological molecular machines.

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  1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997, Moscow, Russia

    V. V. Mesyanzhinov, V. A. Kostyuchenko, L. P. Kurochkina, K. A. Miroshnikov, N. N. Sykilinda & M. M. Shneider

  2. Department of Biological Sciences, Purdue University, 47907-1392, West Lafayette, Indiana, USA

    P. G. Leiman

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Translated from Biokhimiya, Vol. 69, No. 11, 2004, pp. 1463–1476.

Original Russian Text Copyright © 2004 by Mesyanzhinov, Leiman, Kostyuchenko, Kurochkina, Miroshnikov, Sykilinda, Shneider.

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Mesyanzhinov, V.V., Leiman, P.G., Kostyuchenko, V.A. et al. Molecular architecture of bacteriophage T4. Biochemistry (Moscow) 69, 1190–1202 (2004). https://doi.org/10.1007/s10541-005-0064-9

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