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Disorders of Nuclear-Mitochondrial Intergenomic Communication

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Bioscience Reports

Abstract

In the course of evolution, mitochondria lost their independence, and mtDNA became “slave” of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integrity or expression, being inherited as mendelian traits.

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  1. Unit of Molecular Neurogenetics, “C. Besta” Neurological Institute—Foundation IRCCS, via Libero Temolo 4, Milano, 20126, Italy

    Antonella Spinazzola & Massimo Zeviani

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  1. Antonella Spinazzola
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  2. Massimo Zeviani
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Correspondence to Massimo Zeviani.

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Spinazzola, A., Zeviani, M. Disorders of Nuclear-Mitochondrial Intergenomic Communication. Biosci Rep 27, 39–51 (2007). https://doi.org/10.1007/s10540-007-9036-1

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