Abstract
“The Origins of Genome Architecture” by Michael Lynch (2007) may not immediately sound like a book that someone interested in the philosophy of biology would grab off the shelf. But there are three important reasons why you should read this book. Firstly, if you want to understand biological evolution, you should have at least a passing familiarity with evolutionary change at the level of the genome. This is not to say that everyone interested in evolution should be a geneticist or a bioinformatician, but that a working knowledge of genetic change is an essential part of the intellectual toolkit of modern evolutionary biology, even if your primary focus is the evolution of behaviour or the diversity of communities. Secondly, this book provides excellent examples of another important tool in the biologist’s intellectual toolkit, but one that is rarely explained or illustrated to such an extent: null (or neutral) models. The role null models play in testing hypotheses in evolution is a central focus of this book. Thirdly, as an accomplished work of advocacy for a strictly microevolutionary view of evolution, this book provides grist for the mill for the important debate about whether population genetic processes are the sine qua non of evolutionary explanations.
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References
Aguileta G, Bielawski JP, Yang Z (2006) Evolutionary rate variation among vertebrate β-globin genes: implications for dating gene family duplication events. Gene 380:21–29. doi:10.1016/j.gene.2006.04.019
Arthur W (2000) The concept of developmental reprogramming and the quest for an inclusive theory of evolutionary mechanisms. Evol Dev 2:49–57. doi:10.1046/j.1525-142x.2000.00028.x
Bromham L (2002) The human zoo: endogenous retroviruses in the human genome. Trends Ecol Evol 17:91–97. doi:10.1016/S0169-5347(01)02394-1
Burbidge AA, McKenzie NL (1989) Patterns in the modern decline of Western Australia’s vertebrate fauna: causes and conservation implications. Biol Conserv 50:143–198. doi:10.1016/0006-3207(89)90009-8
Burger G, Gray MW, Lang BF (2003) Mitochondrial genomes: anything goes. Trends Genet 19:709–716. doi:10.1016/j.tig.2003.10.012
Calcott B (2009) Lineage explantions: explanating how biological mechanisms change. Br J Philos Sci (in press)
Caporale LH (2003) Darwin in the genome: molecular strategies in biological evolution. McGraw-Hill, New York
Cardillo M, Bromham L (2001) Body size and risk of extinction in Australian mammals. Conserv Biol 15:1435–1440. doi:10.1046/j.1523-1739.2001.00286.x
Carroll RC (2000) Towards a new evolutionary synthesis. Trends Ecol Evol 15:27–32. doi:10.1016/S0169-5347(99)01743-7
Charlesworth B, Langley CH (1989) The population-genetics of drosophila transposable elements. Annu Rev Genet 23:251–287. doi:10.1146/annurev.ge.23.120189.001343
Chisholm R, Taylor R (2007) Null-hypothesis significance testing and the critical weight range for Australian mammals. Conserv Biol 21:1641–1645
Darwin CR (1876) The effects of cross and self fertilisation in the vegetable kingdom. John Murray, London
Dobzhansky T (1973) Nothing in biology makes sense except in the light of evolution. Am Biol Teach 35:125–129
Echols H (1981) SOS functions, cancer and inducible evolution. Cell 25:1–2. doi:10.1016/0092-8674(81)90223-3
Gotelli NJ, Graves GR (1996) Null models in ecology. Smithsonian Institute Press, Washington
Gregory T (2001) Coincidence, coevolution, or causation? DNA content, cell size, and the C-value enigma. Biol Rev Camb Philos Soc 76:65–101. doi:10.1017/S1464793100005595
Harden JH (2008) Quantitative and evolutionary biology of alternative splicing: how changing the mix of alternative transcripts affects phenotypic plasticity and reaction norms. Heredity 100:111–120. doi:10.1038/sj.hdy.6800904
Hersh MA, Ponder RG, Hastings PJ, Rosenberg SM (2004) Adaptive mutation and amplification in Escherischia coli: two pathways of genome adaptation under stress. Res Microbiol 155:352–359. doi:10.1016/j.resmic.2004.01.020
Hubbell S (2001) The unified neutral theory of biodiversity and biogeography. Princeton University Press, New Jersey
Kimura M (1983) The neutral theory of molecular evolution. Cambridge University Press, Cambridge
Kohn M (2004) A reason for everything: natural selection and the English imagination. Faber & Faber, London
Lynch M (2007) The origins of genome architecture. Sinauer Associates, Sunderland Mass
McClintock B (1983) The significance of responses of the genome to challenge. In: Federoff N, Botstein D (eds) Nobel prize lecture: reprinted in The dynamic genome: Barbara McClintock’s ideas in the century of genetics. 1992. Cold Spring Laboratory Press, New York
Mi S, Lee X et al (2000) Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 403:785–789. doi:10.1038/35001608
Ohta T (1973) Slightly deleterious mutant substitutions in evolution. Nature 246:96–98
Shi P, Zhang J, Yang H, Zhang Y-P (2003) Adaptive diversification of bitter tase reecptor genes in mammalian evolution. Mol Biol Evol 20:805–814. doi:10.1093/molbev/msg083
Villareal LP (1997) On viruses, sex and motherhood. J Virol 71:859–865
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Many thanks to Brett Calcott, Kim Sterelny, Meg Woolfit and Rob Lanfear for helpful comments and discussions.
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Bromham, L. Does nothing in evolution make sense except in the light of population genetics?. Biol Philos 24, 387–403 (2009). https://doi.org/10.1007/s10539-008-9146-6
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DOI: https://doi.org/10.1007/s10539-008-9146-6