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Production of recombinant human lactoferrin from transgenic plants

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Biologia Plantarum

Abstract

Molecular farming provides a powerful tool for low cost production of recombinant proteins with pharmaceutical value. The use of transgenic plants has been increasingly tested as alternative system for obtaining biologically active human lactoferrin in plants. Precise selection of plant species, transformation techniques and expression cassettes, in addition to conduction of detailed glycosylation and immunogenicity studies, serves as basis of obtaining safe recombinant human lactoferrin in high concentrations for the use of pharmacy. On the other hand, expression of antimicrobial protein lactoferrin in plants is a promising opportunity for crop quality improvement by increasing plant disease resistance.

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Abbreviations

Lf:

lactoferrin

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Authors and Affiliations

  1. AgroBioInstitute, 8 Dragan Tzankov Blvd., BG-1164, Sofia, Bulgaria

    G. Stefanova, M. Vlahova & A. Atanassov

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  1. G. Stefanova
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  2. M. Vlahova
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  3. A. Atanassov
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Correspondence to G. Stefanova.

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Stefanova, G., Vlahova, M. & Atanassov, A. Production of recombinant human lactoferrin from transgenic plants. Biol Plant 52, 423–428 (2008). https://doi.org/10.1007/s10535-008-0086-4

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