Abstract
Iron is critically important and highly regulated trace metal in the human body. However, in its free ion form, it is known to be cytotoxic; therefore, it is bound to iron storing protein, ferritin. Ferritin is a key regulator of body iron homeostasis able to form various types of minerals depending on the tissue environment. Each mineral, e.g. magnetite, maghemite, goethite, akaganeite or hematite, present in the ferritin core carry different characteristics possibly affecting cells in the tissue. In specific cases, it can lead to disease development. Widely studied connection with neurodegenerative conditions is widely studied, including Alzheimer disease. Although the exact ferritin structure and its distribution throughout a human body are still not fully known, many studies have attempted to elucidate the mechanisms involved in its regulation and pathogenesis. In this review, we try to summarize the iron uptake into the body. Next, we discuss the known occurrence of ferritin in human tissues. Lastly, we also examine the formation of iron oxides and their involvement in brain functions.
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References
Acosta-Cabronero J, Betts MJ, Cardenas-Blanco A et al (2016) In vivo MRI mapping of brain iron deposition across the adult lifespan. J Neurosci 36:364–374. https://doi.org/10.1523/JNEUROSCI.1907-15.2016
Alkhateeb AA, Connor JR (2010) Nuclear ferritin: a new role for ferritin in cell biology. Biochim Biophys Acta 1800:793–797. https://doi.org/10.1016/j.bbagen.2010.03.017
Anderson CP, Shen M, Eisenstein RS, Leibold EA (2012) Mammalian iron metabolism and its control by iron regulatory proteins. Biochim Biophys Acta 1823:1468–1483. https://doi.org/10.1016/j.bbamcr.2012.05.010
Andrews NC (2010) Ferrit(in)ing out new mechanisms in iron homeostasis. Cell Metab 12:203–204. https://doi.org/10.1016/j.cmet.2010.08.011
Arakaki A, Webb J, Matsunaga T (2003) A novel protein tightly bound to bacterial magnetic particles in Magnetospirillum magneticum strain AMB-1. J Biol Chem 278:8745–8750. https://doi.org/10.1074/jbc.M211729200
Archibald DD, Mann S (1993) Template mineralization of self-assembled anisotropic lipid microstructures. Nature 364:430–433. https://doi.org/10.1038/364430a0
Arosio P, Levi S, Santambrogio P et al (1991) Structural and functional studies of human ferritin H and L chains. Curr Stud Hematol Blood Transfus 58:127–131
Baltpurvins KA, Burns RC, Lawrance GA, Stuart AD (1996) Effect of pH and anion type on the aging of freshly precipitated iron(III) hydroxide sludges. Environ Sci Technol 30:939–944. https://doi.org/10.1021/es950401s
Banaclocha MAM, Bokkon I, Banaclocha HM (2010) Long-term memory in brain magnetite. Med Hypotheses 74:254–257. https://doi.org/10.1016/j.mehy.2009.09.024
Barbic M (2019) Possible magneto-mechanical and magneto-thermal mechanisms of ion channel activation in magnetogenetics. Elife 8:1–18. https://doi.org/10.7554/eLife.45807
Benetoli LOB, de Souza CMD, da Silva KL et al (2007) Amino acid interaction with and adsorption on clays: FT-IR and Mössbauer spectroscopy and X-ray diffractometry investigations. Orig Life Evol Biosph 37:479–493. https://doi.org/10.1007/s11084-007-9072-7
Bird AJ (2015) Cellular sensing and transport of metal ions: implications in micronutrient homeostasis. J Nutr Biochem 26:1103–1115. https://doi.org/10.1016/j.jnutbio.2015.08.002
Bleackley MR, Wong AYK, Hudson DM et al (2009) Blood iron homeostasis: newly discovered proteins and iron imbalance. Transfus Med Rev 23:103–123. https://doi.org/10.1016/j.tmrv.2008.12.001
Boča R, Kopáni M, Miglierini M et al (2013) Magnetic and non-magnetic iron-oxide deposits in basal ganglia. Horiz Neurosci Res. 12:135–214
Brem F, Hirt AM, Winklhofer M et al (2006a) Magnetic iron compounds in the human brain: a comparison of tumour and hippocampal tissue. J R Soc Interface 3:833–841. https://doi.org/10.1098/rsif.2006.0133
Brem F, Stamm G, Hirt AM (2006b) Modeling the magnetic behavior of horse spleen ferritin with a two-phase core structure. J Appl Phys. doi 10(1063/1):2206101
Brown JA, Tuszynski JA (1999) A review of the ferroelectric model of microtubules. Ferroelectrics 220:141–155. https://doi.org/10.1080/00150199908216213
Brown S, Sarikaya M, Johnson E (2000) A genetic analysis of crystal growth. J Mol Biol 299:725–735. https://doi.org/10.1006/jmbi.2000.3682
Bulk M, van der Weerd L, Breimer W et al (2018) Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects. Sci Rep 8:6898. https://doi.org/10.1038/s41598-018-25021-7
Cappelletti G, Surrey T, Maci R (2005) The parkinsonism producing neurotoxin MPP+ affects microtubule dynamics by acting as a destabilising factor. FEBS Lett 579:4781–4786. https://doi.org/10.1016/j.febslet.2005.07.058
Carta D, Casula MF, Corrias A et al (2009) Structural and magnetic characterization of synthetic ferrihydrite nanoparticles. Mater Chem Phys 113:349–355. https://doi.org/10.1016/j.matchemphys.2008.07.122
Casadesus G, Smith MA, Zhu X et al (2004) Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. J Alzheimers Dis 6:165–169
Chan CS, Fakra SC, Edwards DC et al (2009) Iron oxyhydroxide mineralization on microbial extracellular polysaccharides. Geochim Cosmochim Acta 73:3807–3818. https://doi.org/10.1016/j.gca.2009.02.036
Chasteen ND, Harrison PM (1999) Mineralization in ferritin: an efficient means of iron storage. J Struct Biol 126:182–194. https://doi.org/10.1006/jsbi.1999.4118
Chasteen ND, Antanaitis BC, Aisen P (1985) Iron deposition in apoferritin. Evidence for the formation of a mixed valence binuclear iron complex. J Biol Chem 260:2926–2929
Chesler M (2003) Regulation and modulation of pH in the brain. Physiol Rev 83:1183–1221. https://doi.org/10.1152/physrev.00010.2003
Chung J, Chen C, Paw BH (2012) Heme metabolism and erythropoiesis. Curr Opin Hematol 19:156–162. https://doi.org/10.1097/MOH.0b013e328351c48b
Coe EM, Bowen LH, Bereman RD (1995a) A Mössbauer and X-ray powder diffraction study of some ferrous hematinics. J Inorg Biochem 58:291–296
Coe EM, Bowen LH, Speer JA et al (1995b) The recharacterization of a polysaccharide iron complex (Niferex). J Inorg Biochem 58:269–278
Coe EM, Bowen LH, Speer JA, Bereman RD (1995c) Comparison of polysaccharide iron complexes used as iron supplements. J Inorg Biochem 57:287–292
Collingwood J, Dobson J (2006) Mapping and characterization of iron compounds in Alzheimer’s tissue. J Alzheimer’s Dis 10:215–222
Collingwood JF, Telling ND (2016) Iron oxides in the human brain. In: Faivre D (ed) Iron oxides. Wiley, Hoboken, pp 143–176
Collingwood JF, Chong RKK, Kasama T et al (2008) Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer’s plaque core material. J Alzheimers Dis 14:235–245
Conrad ME, Umbreit JN (2002) Pathways of iron absorption. Blood Cells Mol Dis 29:336–355. https://doi.org/10.1006/bcmd.2002.0564
Cornell RM, Schwertmann U (2003) The iron oxides-structure, properties, reactions, occurences and uses. Wiley-VCH Verlag GmbH & Co KGaA, Weinheim
Crichton RR, Wilmet S, Legssyer R, Ward RJ (2002) Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells. J Inorg Biochem 91:9–18. https://doi.org/10.1016/S0162-0134(02)00461-0
Dadras A, Riazi GH, Afrasiabi A et al (2013) In vitro study on the alterations of brain tubulin structure and assembly affected by magnetite nanoparticles. JBIC J Biol Inorg Chem 18:357–369. https://doi.org/10.1007/s00775-013-0980-x
Dadras A, Atarod D, Afrasiabi A et al (2015) Neuronal spines can be affected by static magnetic fields: the impact on microtubule dynamic nature. J Adv Med Sci Appl Technol 1:86. https://doi.org/10.18869/nrip.jamsat.1.2.86
Deitmer JW, Schneider HP (1995) Voltage-dependent clamp of intracellular pH of identified leech glial cells. J Physiol 485:157–166. https://doi.org/10.1113/jphysiol.1995.sp020720
Dobson J (2001) Nanoscale biogenic iron oxides and neurodegenerative disease. FEBS Lett 496:1–5. https://doi.org/10.1016/S0014-5793(01)02386-9
Donovan A, Lima CA, Pinkus JL et al (2005) The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 1:191–200. https://doi.org/10.1016/j.cmet.2005.01.003
Dubiel SM, Zablotna-Rypien B, Mackey JB, Williams JM (1999) Magnetic properties of human liver and brain ferritin. Eur Biophys J 28:263–267. https://doi.org/10.1007/s002490050208
Duck KA, Connor JR (2016) Iron uptake and transport across physiological barriers. Biometals 29:1–19. https://doi.org/10.1007/s10534-016-9952-2
Dunn JR, Fuller M, Zoeger J et al (1995) Magnetic material in the human hippocampus. Brain Res Bull 36:149–153
Duret G, Polali S, Anderson ED et al (2019) Magnetic entropy as a proposed gating mechanism for magnetogenetic ion channels. Biophys J 116:454–468. https://doi.org/10.1016/j.bpj.2019.01.003
Duyn JH, Schenck J (2017) Contributions to magnetic susceptibility of brain tissue. NMR Biomed. https://doi.org/10.1002/nbm.3546
El Hage Chahine JM, Hémadi M, Ha-Duong NT (2012) Uptake and release of metal ions by transferrin and interaction with receptor 1. Biochim Biophys Acta 1820:334–347. https://doi.org/10.1016/j.bbagen.2011.07.008
Fisher J, Devraj K, Ingram J et al (2007) Ferritin: a novel mechanism for delivery of iron to the brain and other organs. Am J Physiol Cell Physiol 293:C641–C649. https://doi.org/10.1152/ajpcell.00599.2006
Friedman A, Galazka-Friedman J (2012) The history of the research of iron in parkinsonian substantia nigra. J Neural Transm 119:1507–1510. https://doi.org/10.1007/s00702-012-0894-8
Friedman A, Galazka-Friedman J, Bauminger ER, Koziorowski D (2006) Iron and ferritin in hippocampal cortex and substantia nigra in human brain-implications for the possible role of iron in dementia. J Neurol Sci 248:31–34. https://doi.org/10.1016/j.jns.2006.05.056
Fuqua BK, Vulpe CD, Anderson GJ (2012) Intestinal iron absorption. J Trace Elem Med Biol 26:115–119. https://doi.org/10.1016/j.jtemb.2012.03.015
Galvez N, Fernandez B, Sanchez P et al (2008) Comparative structural and chemical studies of ferritin cores with gradual removal of their iron contents. J Am Chem Soc 130:8062–8068. https://doi.org/10.1021/ja800492z
Garrick MD, Garrick LM (2009) Cellular iron transport. Biochim Biophys Acta 1790:309–325. https://doi.org/10.1016/j.bbagen.2009.03.018
Gažová Z, Antošová A, Krištofiková Z et al (2010) Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer’s disease. Mol Biosyst 6:2200. https://doi.org/10.1039/c003498c
Gossuin Y, Gillis P, Hocq A et al (2009) Magnetic resonance relaxation properties of superparamagnetic particles. Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:299–310. https://doi.org/10.1002/wnan.36
Goya GF, Berquó TS, Fonseca FC, Morales MP (2003) Static and dynamic magnetic properties of spherical magnetite nanoparticles. J Appl Phys 94:3520–3528. https://doi.org/10.1063/1.1599959
Goychuk I (2018) Sensing magnetic fields with magnetosensitive ion channels. Sensors 18:728. https://doi.org/10.3390/s18030728
Grady JK, Shao J, Arosio P et al (2000) Vanadyl(IV) binding to mammalian ferritins. An EPR study aided by site-directed mutagenesis. J Inorg Biochem 80:107–113
Grundke-iqbal I, Wen GY, Shaikh SS et al (1985) Assembly in Alzheimer’s disease failure of microtubule assembly from Alzheimer brain. Lancet 2:421–426
Hamakawa H, Murashita J, Yamada N et al (2004) Reduced intracellular pH in the basal ganglia and whole brain measured by 31P-MRS in bipolar disorder. Psychiatry Clin Neurosci 58:82–88. https://doi.org/10.1111/j.1440-1819.2004.01197.x
Hansel CM, Benner SG, Fendorf S (2005) Competing Fe (II)-induced mineralization pathways of ferrihydrite. Environ Sci Technol 39:7147–7153
Hao Q, Wenfang C, Xia A et al (2011) Effects of a moderate-intensity static magnetic field and adriamycin on K562 cells. Bioelectromagnetics 32:191–199. https://doi.org/10.1002/bem.20625
Harrison PM, Arosio P (1996) The ferritins: molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta 1275:161–203
Hasan MR, Tosha T, Theil EC (2008) Ferritin contains less iron (59 Fe) in cells when the protein pores are unfolded by mutation. J Biol Chem 283:31394–31400. https://doi.org/10.1074/jbc.M806025200
Hautot D, Pankhurst QA, Morris CM et al (2007) Preliminary observation of elevated levels of nanocrystalline iron oxide in the basal ganglia of neuroferritinopathy patients. Biochim Biophys Acta 1772:21–25. https://doi.org/10.1016/j.bbadis.2006.09.011
He D, Marles-Wright J (2015) Ferritin family proteins and their use in bionanotechnology. N Biotechnol 32:651–657. https://doi.org/10.1016/j.nbt.2014.12.006
Hiemstra T, Van Riemsdijk WH (2009) A surface structural model for ferrihydrite I: sites related to primary charge, molar mass, and mass density. Geochim Cosmochim Acta 73:4423–4436. https://doi.org/10.1016/j.gca.2009.04.032
Hurrell R, Egli I (2010) Iron bioavailability and dietary reference values. Am J Clin Nutr 91(5):1461S–1467S
Jacobi N, Herich L (2016) Measurement of liver iron concentration by superconducting quantum interference device biomagnetic liver susceptometry validates serum ferritin as prognostic parameter for allogeneic stem cell transplantation. Eur J Haematol 97:336–341. https://doi.org/10.1111/ejh.12734
Jakus J, Tomori Z, Stransky A, Boselova L (1987) Bulbar respiratory activity during defensive airways reflexes in cats. Acta Physiol Hung 70:245–254
Jurado MJ, Barrón V, Torrent J (2003) Can the presence of structural phosphorus help to discriminate between abiogenic and biogenic magnetites? JBIC J Biol Inorg Chem 8(8):810–814
Kato T, Murashita J, Kamiya A et al (1998) Decreased brain intracellular pH measured by 31P-MRS in bipolar disorder: a confirmation in drug-free patients and correlation with white matter hyperintensity. Eur Arch Psychiatry Clin Neurosci 248:301–306. https://doi.org/10.1007/s004060050054
Kirschvink JL, Kobayashi-Kirschvink A, Woodford BJ (1992) Magnetite biomineralization in the human brain. Proc Natl Acad Sci USA 89:7683–7687
Klemm D (2006) Polysaccharides II. Springer, Berlin
Knight B, Bowen L, Bereman R (1996) Mossbauer studies of some polysaccharide-iron complexes used as hematinics. J Inorg Biochem 64:225–229
Knovich MA, Storey JA, Coffman LG et al (2009) Ferritin for the clinician. Blood Rev 23:95–104. https://doi.org/10.1016/j.blre.2008.08.001
Kokeny P, Cheng YN, Xie H (2018) A study of MRI gradient echo signals from discrete magnetic particles with considerations of several parameters in simulations. Magn Reson Imaging 48:129–137. https://doi.org/10.1016/j.mri.2017.12.019
Kopani M, Kopaniova A, Caplovicova M et al (2014) Iron and its relation to glycoconjugates in human globus pallidus. Bratisl Lek Listy 115:362–366
Kopani M, Miglierini M, Lancok A et al (2015) Iron oxides in human spleen. Biometals 28:913–928
Laufberger V (1937) Sur la cristallisation de la ferritine. Bull Soc chim Biol 19:1575–1582
Lawen A, Lane DJR (2013) Mammalian iron homeostasis in health and disease: uptake, storage, transport, and molecular mechanisms of action. Antioxid Redox Signal 18:2473–2507. https://doi.org/10.1089/ars.2011.4271
Lee EY, Flynn MR, Du G et al (2016) Increased R2* in the caudate nucleus of asymptomatic welders. Toxicol Sci 150:369–377. https://doi.org/10.1093/toxsci/kfw003
Leitner DF, Connor JR (2012) Functional roles of transferrin in the brain. Biochim Biophys Acta 1820:393–402. https://doi.org/10.1016/j.bbagen.2011.10.016
Li W, Garringer HJ, Goodwin CB et al (2015) Systemic and cerebral iron homeostasis in ferritin knock-out Mice. PLoS ONE 10:1–16. https://doi.org/10.1371/journal.pone.0117435
Liu S, Buch S, Chen Y et al (2017) Susceptibility-weighted imaging: current status and future directions. NMR Biomed 30:e3552. https://doi.org/10.1002/nbm.3552
Martínez Banaclocha MA, Bókkon I, Banaclocha HM (2010) Long-term memory in brain magnetite. Med Hypotheses 74:254–257. https://doi.org/10.1016/j.mehy.2009.09.024
McKie AT, Barrow D, Latunde-Dada GO et al (2001) An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 291:1755–1759. https://doi.org/10.1126/science.1057206
Milto IV, Suhodolo IV, Prokopieva VD, Klimenteva TK (2016) Molecular and cellular bases of iron metabolism in humans. Biochem 81:549–564. https://doi.org/10.1134/S0006297916060018
Mir M, Bogachan I, Ms T et al (2012) In vitro study of magnetite-amyloid β complex formation. Nanomed Nanotechnol, Biol Med 8:974–980. https://doi.org/10.1016/j.nano.2011.11.010
Mizutani K, Toyoda M, Mikami B (2012) X-ray structures of transferrins and related proteins. Biochim Biophys Acta 1820:203–211. https://doi.org/10.1016/j.bbagen.2011.08.003
Möller HE, Bossoni L, Connor JR et al (2019) Iron, myelin, and the brain: neuroimaging meets neurobiology. Trends Neurosci 42:384–401. https://doi.org/10.1016/j.tins.2019.03.009
Morgan EH, Oates PS (2002) Mechanisms and regulation of intestinal iron absorption. Blood Cells Mol Dis 29:384–399. https://doi.org/10.1006/bcmd.2002.0578
Morgan EH, Walters MN (1963) Iron storage in human disease: fractionation of hepatic and splenic iron into ferritin and haemosiderin with histochemical correlations. J Clin Pathol 16:101–107
Paige CR, Snodgrass WJ, Nicholson RV, Scharer JM (1997) An arsenate effect on ferrihydrite dissolution kinetics under acidic oxic conditions. Water Res 31(9):2370–2382
Pietrangelo A (2016) Iron and the liver. Liver Int 36:116–123. https://doi.org/10.1111/liv.13020
Piñero DJ, Connor JR (2000) Iron in the brain: an important contributor in normal and diseased states. Neuroscience 6:435–453. https://doi.org/10.1177/107385840000600607
Polanams J, Ray AD, Watt RK (2005) Nanophase iron phosphate, iron arsenate, iron vanadate, and iron molybdate minerals synthesized within the protein cage of ferritin. Inorg Chem 44:3203–3209. https://doi.org/10.1021/ic048819r
Prozorov T, Mallapragada SK, Narasimhan B et al (2007) Protein-mediated synthesis of uniform superparamagnetic magnetite nanocrystals. Adv Funct Mater 17:951–957. https://doi.org/10.1002/adfm.200600448
Przybyszewska J, Zekanowska E (2014) The role of hepcidin, ferroportin, HCP1, and DMT1 protein in iron absorption in the human digestive tract. Prz Gastroenterol 9:208–213. https://doi.org/10.5114/pg.2014.45102
Qiu A, Jansen M, Sakaris A et al (2006) Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 127:917–928. https://doi.org/10.1016/j.cell.2006.09.041
Quintana C (2007) Contribution of analytical microscopies to human neurodegenerative diseases research (PSP and AD). Mini Rev Med Chem 7:961–975
Quintana C, Gutiérrez L (2010) Could a dysfunction of ferritin be a determinant factor in the aetiology of some neurodegenerative diseases? Biochim Biophys Acta 1800:770–782. https://doi.org/10.1016/j.bbagen.2010.04.012
Rohrer JS, Islam QT, Watt GD et al (1990) Iron environment in ferritin with large amounts of phosphate, from Azotobacter vinelandii and horse spleen, analyzed using extended X-ray absorption fine structure (EXAFS). Biochemistry 29:259–264
Saito H (2014) Metabolism of iron stores. Nagoya J Med Sci 76:235–254. https://doi.org/10.1210/jcem-36-2-365
Schwertmann U, Friedl J, Stanjek H (1999) From Fe(III) ions to ferrihydrite and then to hematite. J Colloid Interface Sci 209:215–223. https://doi.org/10.1006/jcis.1998.5899
Schwertmann U, Friedl J, Stanjek H, Schulze DG (2000) The effect of clay minerals on the formation of goethite and hematite from ferrihydrite after 16 years’ ageing at 25°C and pH 4–7. Clay Miner 35:613–623. https://doi.org/10.1180/000985500547034
Sharp P, Srai S (2007) Molecular mechanisms involved in intestinal iron absorption. World J Gastroenterol 13:4716–4724
Shayeghi M, Latunde-Dada GO, Oakhill JS et al (2005) Identification of an intestinal heme transporter. Cell 122:789–801. https://doi.org/10.1016/j.cell.2005.06.025
Shevtsov PN, Shevtsova EF, Burbaeva GS, Bachurin SO (2006) Disturbed assembly of human cerebral microtubules in Alzheimer’s disease. Bull Exp Biol Med 141:265–268. https://doi.org/10.1007/s10517-006-0145-9
Simovich M, Hainsworth LN, Fields PA et al (2003) Localization of the iron transport proteins mobilferrin and DMT-1 in the duodenum: the surprising role of mucin. Am J Hematol 74:32–45. https://doi.org/10.1002/ajh.10383
Sipos P, Berkesi O, Tombácz E et al (2003) Formation of spherical iron(III) oxyhydroxide nanoparticles sterically stabilized by chitosan in aqueous solutions. J Inorg Biochem 95:55–63. https://doi.org/10.1016/S0162-0134(03)00068-0
Stpierre TG, Dobson J (2000) Theoretical evaluation of cell membrane ion channel activation by applied magnetic fields. Eur Biophys J 29:455–456
Stoyanovsky DA, Tyurina YY, Shrivastava I et al (2019) Iron catalysis of lipid peroxidation in ferroptosis: regulated enzymatic or random free radical reaction? Free Radic Biol Med 133:153–161. https://doi.org/10.1016/j.freeradbiomed.2018.09.008
Sun S, Chasteen ND (1992) Ferroxidase kinetics of horse spleen apoferritin. J Biol Chem 267:25160–25166
Surguladze N, Patton S, Cozzi A et al (2005) Characterization of nuclear ferritin and mechanism of translocation. Biochem J 388:731–740. https://doi.org/10.1042/BJ20041853
Teller S, Tahirbegi IB, Mir M et al (2015) Magnetite-amyloid-β deteriorates activity and functional organization in an in vitro model for Alzheimer’s disease. Sci Rep 5:1–16. https://doi.org/10.1038/srep17261
Theil EC (2003) Metal-binding proteins and trace element metabolism ferritin: at the crossroads of iron and oxygen metabolism 1, 2. J Nutr 133:1549–1553
Tong S, Zhu H, Bao G (2019) Magnetic iron oxide nanoparticles for disease detection and therapy. Mater Today. https://doi.org/10.1016/j.mattod.2019.06.003
Treffry A, Bauminger ER, Hechel D et al (1993) Defining the roles of the threefold channels in iron uptake, iron oxidation and iron-core formation in ferritin: a study aided by site-directed mutagenesis. Biochem J 296:721–728. https://doi.org/10.1042/bj2960721
Tuszyński JA, Hameroff S, Satarić MV et al (1995) Ferroelectric behavior in microtubule dipole lattices: implications for information processing, signaling and assembly/disassembly. J Theor Biol 174:371–380. https://doi.org/10.1006/jtbi.1995.0105
Umbreit JN, Conrad ME, Hainsworth LN, Simovich M (2002) The ferrireductase paraferritin contains divalent metal transporter as well as mobilferrin. Am J Physiol Liver Physiol 282:G534–G539. https://doi.org/10.1152/ajpgi.00199.2001
Van Rensburg SJ, Kotze MJ, Van Toorn R (2012) The conundrum of iron in multiple sclerosis: time for an individualised approach. Metab Brain Dis 27:239–253. https://doi.org/10.1007/s11011-012-9290-1
Wally J, Halbrooks PJ, Vonrhein C et al (2006) The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding. J Biol Chem 281:24934–24944. https://doi.org/10.1074/jbc.M604592200
Walters GO, Miller FM, Worwood M (1973) Serum ferritin concentration and iron stores in normal subjects. J Clin Pathol 26:770–772. https://doi.org/10.1136/jcp.26.10.770
Weinberg ED (2009) Iron toxicity: new conditions continue to emerge. Oxid Med Cell Longev 2:107–109
Wessling-Resnick M (2000) Iron transport. Annu Rev Nutr 20:129–151. https://doi.org/10.1146/annurev.nutr.20.1.129
Worwood M, Aherne W, Dawkins S, Jacobs A (1975) The characteristics of ferritin from human tissues, serum and blood cells. Clin Sci Mol Med 48:441–451
Yang CY, Bryan AM, Theil EC et al (1986) Structural variations in soluble iron complexes of models for ferritin: an x-ray absorption and Mössbauer spectroscopy comparison of horse spleen ferritin to Blutal (iron-chondroitin sulfate) and Imferon (iron-dextran). J Inorg Biochem 28:393–405
Ye SR, Yang JW, Chen CM (2004) Effect of static magnetic fields on the amplitude of action potential in the lateral giant neuron of crayfish. Int J Radiat Biol 80:699–708. https://doi.org/10.1080/09553000400017424
Yim EKF, Darling EM, Kulangara K et al (2010) Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells. Biomaterials 31:1299–1306. https://doi.org/10.1016/j.biomaterials.2009.10.037
Zeineh MM, Chen Y, Kitzler HH et al (2015) Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease. Neurobiol Aging 36:2483–2500. https://doi.org/10.1016/j.neurobiolaging.2015.05.022
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The work was financially supported by Slovak grant agencies APVV 16-0039 and SK-SRB-2016-0055.
This manuscript was approved by Prof. James Connor, Professor of Neurosurgery, Penn State University, Vice-Chair of Neurosurgery Research, Director, Center for Aging and Neurodegenerative Diseases.
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Svobodova, H., Kosnáč, D., Tanila, H. et al. Iron–oxide minerals in the human tissues. Biometals 33, 1–13 (2020). https://doi.org/10.1007/s10534-020-00232-6
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DOI: https://doi.org/10.1007/s10534-020-00232-6