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High Selenium Yeast mitigates aluminum-induced cerebral inflammation by increasing oxidative stress and blocking NO production

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Abstract

High Selenium Yeast (SeY) serves many important roles with respect to the maintenance of normal nervous system functioning. Studies have reported the nerve inflammation induced by Aluminum (Al) was associated with the increase of mortality. However, in-depth studies are required to verify the hypothesized neuro-protective efficacy of SeY against Al-induced cerebral damage through modulation of the inflammatory response. Here, mice were treated with SeY (0.1 mg/kg) and/or Al (10 mg/kg) by oral gavage for 28 days. Inflammation was assessed by histopathological examination and expression of biomarkers for inflammation. Furthermore, the oxidation–reduction levels and the NO production were assessed using diagnostic kits and RT-PCR. The data indicated that SeY significantly protected cerebrum against Al-induced pathological changes, in addition to the disordered expression of biomarkers of inflammation, the imbalance of oxidation–reduction, and the increase of NO production. Therefore, the chemoprotective potential of SeY against Al-induced cerebral inflammation via restore the levels of oxidation–reduction and the generation of NO was demonstrated.

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Acknowledgements

This work was supported by Foshan University research star-up project (099/gg07037) and Key Laboratory of preventive veterinary medicine in Guangdong Provincial Department of Education (2014KTSPT037).

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  1. Changyu Cao and Xiaowen Li contributed equally to this work.

Authors and Affiliations

  1. College of Life Science, Foshan University, Foshan, 528231, Guangdong, People’s Republic of China

    Changyu Cao, Xiaowen Li, Junchong Luo, Mengdan Zhang, Zijian Ou & Kai Wang

  2. Laboratory Animal Center, Qiqihar Medical University, Qiqihar, 161006, Heilongjiang, People’s Republic of China

    Lei Qin

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  1. Changyu Cao
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  2. Xiaowen Li
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  3. Lei Qin
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  4. Junchong Luo
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  5. Mengdan Zhang
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  6. Zijian Ou
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  7. Kai Wang
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Correspondence to Changyu Cao or Kai Wang.

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Cao, C., Li, X., Qin, L. et al. High Selenium Yeast mitigates aluminum-induced cerebral inflammation by increasing oxidative stress and blocking NO production. Biometals 31, 835–843 (2018). https://doi.org/10.1007/s10534-018-0128-0

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  • DOI: https://doi.org/10.1007/s10534-018-0128-0

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