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Zinc and myocardial ischemia/reperfusion injury

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Abstract

As an important trace element, zinc is required for the normal cellular structure and function, and impairment of zinc homeostasis is associated with a variety of health problems including cardiovascular disease. Zinc homeostasis is regulated through zinc transporters, zinc binding molecules, and zinc sensors. Zinc also plays a critical role in cellular signaling. Studies have documented that zinc homeostasis is impaired by ischemia/reperfusion in the heart and zinc dyshomeostasis may play a role in the pathogenesis of myocardial ischemia/reperfusion injury. Both exogenous and endogenously released zinc may play an important role in cardioprotection against ischemia/reperfusion injury. The goal of this review is to summarize the current understanding of the roles of zinc homeostasis and zinc signaling in myocardial ischemia/reperfusion injury.

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  1. Department of Physiology & Pathophysiology, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, People’s Republic of China

    Zhelong Xu

  2. Department of Physiology & Pathophysiology, Xian Jiaotong University, Xian, 710061, Shanxi, People’s Republic of China

    Juan Zhou

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  1. Zhelong Xu
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Xu, Z., Zhou, J. Zinc and myocardial ischemia/reperfusion injury. Biometals 26, 863–878 (2013). https://doi.org/10.1007/s10534-013-9671-x

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