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High expression of growth factor receptor-bound protein 14 predicts poor prognosis for colorectal cancer patients

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Abstract

Objects

To explore the roles of growth factor receptor-bound protein 14 (GRB14) in colorectal cancer (CRC) and its correlation with clinicopathological characteristics and prognosis of CRC patients.

Results

GRB14 was localized in the cytoplasm of CRC and benign glandular epithelium cells, showing higher levels in CRC tissues compared with normal colon samples (P < 0.001). High GRB14 was associated with a high pathological grade (P = 0.045), advanced clinical stage (P = 0.018), enhanced tumor invasion (P < 0.001) and lymph node metastasis (P = 0.028). The cancer genome atlas (TCGA) mRNA sequence data showed that GRB14 was upregulated in CRC at an advanced clinical stage (P = 0.011) with enhanced tumor invasion (P < 0.001) and lymph node metastasis (P = 0.014). Kaplan–Meier survival curves revealed that CRC patients with high GRB14 levels had a shorter survival compared with those showing low GRB14 expression (P = 0.007). High GRB14 expression was an independent prognostic factor for CRC patients (HR 2.847, 95 %CI 1.058–7.659; P = 0.038).

Conclusions

GRB14 may be an important cancer promoter that enhances CRC progression. Upregulated GRB14 levels may predict a poor clinical outcome in CRC patients.

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Acknowledgments

The present study was supported by the Grant from National Natural Science Foundation of China (81272556).

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Authors and Affiliations

  1. Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, Guangzhou Medical University, Panfu Road No. 1, Guangzhou, 510180, China

    Ping Yang, Jianchang Wei, Wanglin Li, Feng He, Shanqi Zeng, Tong Zhang, Zheng Sun & Jie Cao

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  1. Ping Yang
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  2. Jianchang Wei
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  3. Wanglin Li
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  4. Feng He
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  5. Shanqi Zeng
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  6. Tong Zhang
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  7. Zheng Sun
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  8. Jie Cao
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Correspondence to Jie Cao.

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Yang, P., Wei, J., Li, W. et al. High expression of growth factor receptor-bound protein 14 predicts poor prognosis for colorectal cancer patients. Biotechnol Lett 38, 1043–1047 (2016). https://doi.org/10.1007/s10529-016-2077-4

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  • DOI: https://doi.org/10.1007/s10529-016-2077-4

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