Abstract
Methyl (R)-2-chloromandelate, a key intermediate in the synthesis of clopidogrel, was obtained by the reduction of methyl-2-chlorobenzoylformate using whole cells of Saccharomyces cerevisiae. A 100% conversion and 96.1% of enantiomeric excess (ee) value was obtained when 17 methyl-2-chlorobenzoylformate/l was reacted with 8 g S. cerevisiae/l and 83 g glucose/l at pH 7.
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This work was supported by the 2009 Research Fund of University of Ulsan.
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Jeong, M., Lee, Y.M., Hong, S.H. et al. Optimization of enantioselective synthesis of methyl (R)-2-chloromandelate by whole cells of Saccharomyces cerevisiae . Biotechnol Lett 32, 1529–1531 (2010). https://doi.org/10.1007/s10529-010-0396-4
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DOI: https://doi.org/10.1007/s10529-010-0396-4