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Synergistic effects of ovine-derived cathelicidins and other antimicrobials against Escherichia coli O157:H7 and Staphylococcus aureus 1056 MRSA

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Abstract

Synergistic effects of ovine-derived cathelicidins SMAP29 and OaBac5mini with the antimicrobials polymyxin B, lysozyme, nisin and lactoferrin were investigated against E. coli O157:H7 and S. aureus 1056 MRSA. Lysozyme showed synergy against E. coli O157:H7 with SMAP29, polymyxin B and lactoferrin. Synergy was also found between SMAP29 and lactoferrin against this host. Against S. aureus 1056 MRSA, lysozyme showed synergy with OaBac5mini, polymyxin B and nisin, while synergy was also found between nisin and OaBac5mini and polymyxin B. Other combinations of the antimicrobials were either additive or non-synergistic.

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Acknowledgement

This work was supported by Meat Biologics Research Limited and the Massey University Research Fund.

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Authors and Affiliations

  1. Biotechnology Group, School of Engineering and Advanced Technology, Massey University, Private Bag 11-222, Palmerston North, 4442, New Zealand

    Danitsja S. van der Linden, David Short, Antje Dittmann & Pak-Lam Yu

Authors
  1. Danitsja S. van der Linden
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  2. David Short
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  3. Antje Dittmann
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  4. Pak-Lam Yu
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Correspondence to Pak-Lam Yu.

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van der Linden, D.S., Short, D., Dittmann, A. et al. Synergistic effects of ovine-derived cathelicidins and other antimicrobials against Escherichia coli O157:H7 and Staphylococcus aureus 1056 MRSA. Biotechnol Lett 31, 1265–1267 (2009). https://doi.org/10.1007/s10529-009-0010-9

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  • DOI: https://doi.org/10.1007/s10529-009-0010-9

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