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Changes in primary metabolism leading to citric acid overflow in Aspergillus niger

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Abstract

For citric acid-accumulating Aspergillus niger cells, the enhancement of anaplerotic reactions replenishing tricarboxylic acid cycle intermediates predisposes the cells to form the product. However, there is no increased citrate level in germinating spores and a complex sequence of developmental events is needed to change the metabolism in a way that leads to an increased level of tricarboxylic acid cycle intermediates in mycelia. A review of physiological events that cause such intracellular conditions, with the special emphasis on the discussion of hexose transport into the cells and regulation of primary metabolism, predominantly of glycolytic flux during the process, is presented.

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Authors and Affiliations

  1. National Institute of Chemistry, Hajdrihova 19, Si-1001, Ljubljana, Slovenia

    Matic Legiša

  2. University of Strathclyde, 204 George Street, G1 1XW, Glasgow, Scotland

    Michael Mattey

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  1. Matic Legiša
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  2. Michael Mattey
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Correspondence to Matic Legiša.

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Legiša, M., Mattey, M. Changes in primary metabolism leading to citric acid overflow in Aspergillus niger . Biotechnol Lett 29, 181–190 (2007). https://doi.org/10.1007/s10529-006-9235-z

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  • DOI: https://doi.org/10.1007/s10529-006-9235-z

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