Abstract
Modified nucleosides can be prepared by microbial transglycosylation from cheaper nucleoside precursors using free or immobilised whole cells. An efficient screening method to find transglycosylation activity in␣microorganisms was developed for the synthesis of 6-modified purine nucleosides, such as 6-chloro-, 6-methoxy-, 6-iodo- and 6-mercaptopurine ribonucleoside. Out of 100 microorganisms screened, Bacillus stearothermophilus ATCC 12980 was the best for this purpose.
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Trelles, J., Valino, A., Runza, V. et al. Screening of Catalytically Active Microorganisms for the Synthesis of 6-Modified Purine Nucleosides. Biotechnol Lett 27, 759–763 (2005). https://doi.org/10.1007/s10529-005-5628-7
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DOI: https://doi.org/10.1007/s10529-005-5628-7