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A Crosstalk on Codon Usage in Genes Associated with Leukemia

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Abstract

Leukemia is the outcome of aggregation of damaged white blood cells. Several genes were reported to be associated with the pathogenesis of leukemia. These genes were computationally analyzed to decipher their codon usage bias (CUB) and to identify the prime factors influencing the codon usage profile as no work was reported yet. The mean values of synonymous codon usage order (SCUO) parameter indicated low CUB of the genes. Significant positive association of SCUO with overall GC and positional GCs might signal the presence of mutational pressure. However, neutrality plot suggested the dominant role of natural selection across the genes. Along with natural selection, the role of mutation pressure was also prominent and that might be responsible for lower CUB (SCUO = 0.19) of genes. Low translational speed might permit accuracy in the process. A strong inverse relationship of translational rate was observed with CUB of genes and folding energy.

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Acknowledgements

The authors are thankful to Assam University, Silchar, Assam, India, for providing necessary facilities.

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The work was not supported by any national or international organization.

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Authors and Affiliations

  1. Department of Biotechnology, Assam University, Silchar, Assam, 788011, India

    Supriyo Chakraborty, Durbba Nath, Sunanda Paul & Yashmin Choudhury

  2. Department of Biomedical Science, Hallym University, Hallymdachak-gil, Chuncheon, 24252, Gangwon-do, Korea

    Yeongseon Ahn & Yoon Shin Cho

  3. Department of Zoology, Moinul Hoque Choudhury Memorial Science College, Algapur, Hailakandi, Assam, 788150, India

    Arif Uddin

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  1. Supriyo Chakraborty
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  2. Durbba Nath
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Correspondence to Supriyo Chakraborty.

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Chakraborty, S., Nath, D., Paul, S. et al. A Crosstalk on Codon Usage in Genes Associated with Leukemia. Biochem Genet 59, 235–255 (2021). https://doi.org/10.1007/s10528-020-10000-3

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