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Genetic Polymorphism of Interferon-γ, Interferon-γ Receptor, and Interferon Regulatory Factor-1 Genes in Patients with Hepatitis B Virus Infection

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The natural history of hepatitis B virus (HBV) infection is probably related to host immune factors. Interferon-γ (IFN-γ) plays significant roles in immune defense. This study was undertaken to investigate the association between HBV infection and single nucleotide polymorphisms (SNPs) of IFN-γ, IFN-γ receptor (IFNGR)-1 and 2, and interferon regulatory factor (IRF)-1 genes. Between March 2002 and December 2002, 614 Korean patients were enrolled in two different groups: an HBV clearance group (n = 201), who were hepatitis B surface antigen (HBsAg) negative with antibodies to HBsAg and hepatitis B core antigen, and an HBV persistence group (n = 413), who were repeatedly HBsAg positive. We assessed polymorphisms in the IFN-γ gene at position +874, in the IFNGR-1 gene at positions −56 and +95, in the IFNGR-2 gene at the second position of codon 64 (Gln64Arg), and in the IRF-1 gene promoter (−410, −388), and the genotype distributions of the HBV clearance and persistence groups were compared. On the basis of unconditional logistic regression analysis with adjustment for age and sex, no statistically significant association with susceptibility to persistent HBV infection was observed with the IFN-γ, IFNGR-1 and 2, and IRF-1 gene polymorphisms under the codominant, dominant, and recessive models.

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Acknowledgments

This study was supported by a grant from the Korean Health R&D project, Ministry of Health and Welfare, Republic of Korea (01-PJ10-PG6-01GN14-0007).

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Authors and Affiliations

  1. Department of Gastroenterology, Genomic Research Center for Gastroenterology, Ajou University School of Medicine, San-5 Wonchon-Dong, Youngtong-ku, Suwon, South Korea

    Jae Youn Cheong, Sung Won Cho, Soon Gee Chung, Jung A. Lee, Marie Yeo, Ki Baik Hahm & Jin Hong Kim

  2. Department of General Surgery, Ajou University School of Medicine, Suwon, South Korea

    Hee Jung Wang

  3. DNA Link Co., Seoul, South Korea

    Jong Eun Lee

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  1. Jae Youn Cheong
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  2. Sung Won Cho
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  3. Soon Gee Chung
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  4. Jung A. Lee
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  5. Marie Yeo
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  6. Hee Jung Wang
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  9. Jin Hong Kim
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Correspondence to Sung Won Cho.

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Cheong, J., Cho, S., Chung, S. et al. Genetic Polymorphism of Interferon-γ, Interferon-γ Receptor, and Interferon Regulatory Factor-1 Genes in Patients with Hepatitis B Virus Infection. Biochem Genet 44, 246–255 (2006). https://doi.org/10.1007/s10528-006-9029-y

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  • DOI: https://doi.org/10.1007/s10528-006-9029-y

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