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Antisense oligonucleotides inhibiting ribosomal functions in mycobacteria

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Abstract

We studied the binding of antisense oligonucleotides with 23S rRNA of mycobacteria and E. coli and identified oligonucleotides with selective affinity to the α-sarcin loop region of 23S rRNA of M. tuberculosis and to 70S ribosomes of M. smegmatis. These oligonucleotides proved to selectively inhibit protein synthesis on M. smegmatis ribosomes.

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Authors and Affiliations

  1. Novosibirsk Institute of Bioorganic Chemistry, Siberian Division, Russian Academy of Sciences, pr. Akademika Lavrent’eva 8, 630090, Novosibirsk, Russia

    Yu. N. Demchenko, M. A. Zenkova & V. V. Vlassov

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  1. Yu. N. Demchenko
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  2. M. A. Zenkova
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  3. V. V. Vlassov
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Translated from Izvestiya Akademii Nauk, Seriya Biologicheskaya, No. 2, 2005, pp. 133–140.

Original Russian Text Copyright © 2005 by Demchenko, Zenkova, Vlassov.

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Demchenko, Y.N., Zenkova, M.A. & Vlassov, V.V. Antisense oligonucleotides inhibiting ribosomal functions in mycobacteria. Biol Bull Russ Acad Sci 32, 101–107 (2005). https://doi.org/10.1007/s10525-005-0015-4

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  • DOI: https://doi.org/10.1007/s10525-005-0015-4

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