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Age-related Alterations of Apolipoprotein E and Interleukin-1β in the Aging Brain

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Abstract

With normal aging, the brain undergoes several alterations including reduced neuronal functioning and alterations in glia homeostasis. An increase in inflammatory signaling has also been reported in some studies of the aging brain, with inflammation potentially mediating age-related changes in the brain. Apolipoprotein E (ApoE) is produced in the brain and has been shown to possess anti-inflammatory properties in a variety of paradigms. In the present study, we correlated age-related alterations in ApoE expression with age-related changes in the cytokine interleukin-1 beta (IL-1β), in the brain of rats of increasing age. No significant alteration in ApoE mRNA was found in any region examined. A significant increase in IL-1β mRNA with age was observed only in the cortex. Neither ApoE nor IL-1β protein expression was significantly altered with age in the brain. A significant linear correlation between ApoE and IL-1β mRNA was found in the cortex but not in the striatum or hippocampus. No correlation was found between ApoE and IL-1β protein in any region examined. Taken together, these studies demonstrate that ApoE expression is not altered during normal brain aging, but suggest that there may be a relationship between ApoE and IL-1β transcription in the cerebral cortex.

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Authors and Affiliations

  1. Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY, 40536-230, USA

    Jillian R. Gee, Qunxing Ding & Jeffrey N. Keller

  2. Sanders-Brown Center on Aging, University of Kentucky, 205 Sanders Brown Building, 800 S. Limestone, Lexington, KY, 40536-0230, USA

    Jeffrey N. Keller

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  1. Jillian R. Gee
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  2. Qunxing Ding
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  3. Jeffrey N. Keller
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Correspondence to Jeffrey N. Keller.

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Gee, J.R., Ding, Q. & Keller, J.N. Age-related Alterations of Apolipoprotein E and Interleukin-1β in the Aging Brain. Biogerontology 7, 69–79 (2006). https://doi.org/10.1007/s10522-005-6039-9

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  • DOI: https://doi.org/10.1007/s10522-005-6039-9

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