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The National Longitudinal Study of Adolescent to Adult Health (Add Health) Sibling Pairs Genome-Wide Data

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Abstract

Here we provide a detailed description of the genome-wide information available on the National Longitudinal Study of Adolescent to Adult Health (Add Health) sibling pair subsample (Harris et al. in Twin Res Hum Genet 16:391–398, 2013). A total of 2,020 samples were genotyped (including duplicates) arising from 1946 Add Health individuals from the sibling pairs subsample. After various steps for quality control (QC) and quality assurance (QA), we have high quality genome-wide data available on 1,888 individuals. In this report, we first highlight the QC and QA steps that were taken to prune the data of poorly performing samples and genetic markers. We further estimate the pairwise biological relationships using genome-wide data and compare those estimates to the assumed relationships in Add Health. Additionally, using genome-wide data from known regional reference populations from Europe, West Africa, North and South America, Japan and China, we estimate the relative genetic ancestry of the respondents. Finally, rather than conducting a traditional cross-sectional genome-wide association study (GWAS) of body mass index (BMI), we opted to utilize the extensive publicly available genome-wide information to conduct a weighted GWAS of longitudinal BMI while accounting for both family and ethnic variation.

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Acknowledgments

This research uses data from Add Health, a program project directed by Kathleen Mullan Harris and designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris at the University of North Carolina at Chapel Hill, and funded by Grant P01-HD31921 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, with cooperative funding from 23 other federal agencies and foundations. Information on how to obtain the Add Health data files is available on the Add Health website (http://www.cpc.unc.edu/addhealth). The genome-wide data generated for the Add Health sibling pairs subsample as well investigator effort for MBM, JDB, KMH, BD and AS was funded by Grant R01-HD060726 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Conflict of Interest

Matthew McQueen, Jason Boardman, Benjamin Domingue, Andrew Smolen, Joyce Tabor, Ley Killeya-Jones, Carolyn Halpern, Eric Whitsel and Kathleen Harris declare they have no conflicts of interest.

Human and Animal Rights and Informed Consent

All procedures were followed in accordance with the ethical standards of the UNC-Chapel Hill and CU Boulder IRB committees. Informed consent was obtained from all participants.

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Authors and Affiliations

  1. Department of Integrative Physiology, University of Colorado Boulder, 354 UCB, Boulder, USA

    Matthew B. McQueen

  2. Institute of Behavioral Science, University of Colorado Boulder, Boulder, USA

    Jason D. Boardman & Benjamin W. Domingue

  3. Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, USA

    Andrew Smolen

  4. Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, USA

    Joyce Tabor, Ley Killeya-Jones, Carolyn T. Halpern & Kathleen Mullan Harris

  5. Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA

    Carolyn T. Halpern

  6. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA

    Eric A. Whitsel

  7. Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA

    Eric A. Whitsel

  8. Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, USA

    Kathleen Mullan Harris

  9. Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, USA

    Kathleen Mullan Harris

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  1. Matthew B. McQueen
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  2. Jason D. Boardman
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  3. Benjamin W. Domingue
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  4. Andrew Smolen
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  5. Joyce Tabor
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  8. Eric A. Whitsel
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  9. Kathleen Mullan Harris
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Correspondence to Matthew B. McQueen.

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McQueen, M.B., Boardman, J.D., Domingue, B.W. et al. The National Longitudinal Study of Adolescent to Adult Health (Add Health) Sibling Pairs Genome-Wide Data. Behav Genet 45, 12–23 (2015). https://doi.org/10.1007/s10519-014-9692-4

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