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The D2 Dopamine Receptor Gene and Nicotine Dependence Among Bladder Cancer Patients and Controls

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Abstract

Multiple twin, family, and genetic studies have rendered substantial evidence supporting an association between hereditary factors and smoking initiation and maintenance. To investigate further the relationships between the DRD2 genotypes, cigarette use and nicotine dependence, we examined the prevalence of polymorphisms in the TaqIA (A1 and A2) and the TaqIB (B1 and B2) alleles among a series of 608 non-Hispanic White bladder cancer patients and 608 matched controls. Among ever-smoking controls, A1 and B1 genotypes exhibited a greater smoking intensity and were significantly younger at the age of initiation than A2A2 or B2B2 genotypes (two-sided P < 0.05). Among former smoking cases, persons with the A1 genotypes exhibited significantly higher mean pack-years and years of smoking, and were younger at the age of initiation than were persons with the A2A2 genotype (two-sided P < 0.05). Additionally, current smokers with the A1 genotypes reported fewer quit attempts than those with the A2A2 genotype (two-sided P < 0.01). The present study suggests that the DRD2 alleles A1 and B1 confer greater vulnerability to tobacco use.

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Acknowledgments

The work reported here was supported by National Cancer Institutes grants CA 74880 and CA 91846, Xifeng Wu, Ph.D., Principle Investigator, and by a cancer prevention fellowship supported by the National Cancer Institute grant R25 CA57730, Robert M. Chamberlain, Ph.D., Principle Investigator.

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Authors and Affiliations

  1. Department of Epidemiology, Unit 1340, The University of Texas M. D. Anderson Cancer Center, 1155 Pressler Blvd. Unit 1340, Houston, TX, 77030, USA

    Jessica Clague & Xifeng Wu

  2. Department of Behavioral Science, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

    Paul Cinciripini & Janice Blalock

  3. Department of Pharmacy Practice, Purdue University School of Pharmacy, West Lafayette, IN, USA

    Karen S. Hudmon

Authors
  1. Jessica Clague
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  2. Paul Cinciripini
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  3. Janice Blalock
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  4. Xifeng Wu
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  5. Karen S. Hudmon
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Correspondence to Xifeng Wu.

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Edited by Tatiana Foroud.

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Clague, J., Cinciripini, P., Blalock, J. et al. The D2 Dopamine Receptor Gene and Nicotine Dependence Among Bladder Cancer Patients and Controls. Behav Genet 40, 49–58 (2010). https://doi.org/10.1007/s10519-009-9301-0

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  • DOI: https://doi.org/10.1007/s10519-009-9301-0

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