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A Cholinergic Receptor Gene (CHRM2) Affects Event-related Oscillations

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Abstract

We report genetic linkage and association findings which implicate the gene encoding the muscarinic acetylcholine receptor M2 (CHRM2) in the modulation of a scalp-recorded electrophysiological phenotype. The P3 (P300) response was evoked using a three-stimulus visual oddball paradigm and a phenotype that relates to the energy in the theta band (4–5 Hz) was analyzed. Studies have shown that similar electrophysiological measures represent cognitive correlates of attention, working memory, and response selection; a role has been suggested for the ascending cholinergic pathway in the same functions. The results of our genetic association tests, combined with knowledge regarding the presence of presynaptic cholinergic M2 autoreceptors in the basal forebrain, indicate that the cognitive processes required by the experiment may in part be mediated by inhibitory neural networks. These findings underscore the utility of electrophysiology and neurogenetics in the understanding of cognitive function and the study of brain-related disorders.

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Acknowledgments

The Collaborative Study on the Genetics of Alcoholism (COGA) (Principal Investigator: H. Begleiter; Co-Principal Investigators: L. Bierut, H. Edenberg, V. Hesselbrock, B. Porjesz) includes nine different centers where data collection, analysis, and storage take place. The nine sites and Principal Investigators and Co-Investigators are: University of Connecticut (V. Hesselbrock); Indiana University (H. Edenberg, J. Nurnberger Jr., P.M. Conneally, T. Foroud); University of Iowa (S. Kuperman, R. Crowe); SUNY HSCB (B. Porjesz, H. Begleiter); Washington University in St. Louis (L. Bierut, A. Goate, J. Rice); University of California at San Diego (M. Schuckit); Howard University (R. Taylor); Rutgers University (J. Tischfield); Southwest Foundation (L. Almasy). Zhaoxia Ren serves as the NIAAA Staff Collaborator. This national collaborative study is supported by the NIH Grant U10AA08401 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA).

In memory of Theodore Reich, M.D., Co-Principal Investigator of COGA since its inception and one of the founders of modern psychiatric genetics, we acknowledge his immeasurable and fundamental scientific contributions to COGA and the field.

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Authors and Affiliations

  1. Department of Psychiatry, SUNY Health Science Center, 450 Clarkson Avenue, Box 1203, Brooklyn, NY, 11203, USA

    Kevin A. Jones, Bernice Porjesz & Henri Begleiter

  2. Southwest Foundation for Biomedical Research, San Antonio, TX, USA

    Laura Almasy

  3. Washington University School of Medicine, St. Louis, MO, USA

    Laura Bierut, Danielle Dick, Alison Goate, Anthony Hinrichs, John P. Rice, Jen C. Wang & John Rohrbaugh

  4. University of Connecticut, Farmington, CT, USA

    Lance O. Bauer & Victor Hesselbrock

  5. University of Iowa, Psychiatry Research, Iowa City, IA, USA

    Raymond Crowe & Samuel Kuperman

  6. Indiana University School of Medicine, Indianapolis, IN, USA

    Tatiana Foroud, John Nurnberger Jr., Sean J. O’Connor & Howard J. Edenberg

  7. University of California, San Diego, CA, USA

    Marc A. Schuckit

  8. Rutgers University, Piscataway, NJ, USA

    Jay Tischfield

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  1. Kevin A. Jones
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  2. Bernice Porjesz
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  15. John Nurnberger Jr.
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  20. Howard J. Edenberg
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  21. Henri Begleiter
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Correspondence to Bernice Porjesz.

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Edited by Peter McGuffin

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Jones, K.A., Porjesz, B., Almasy, L. et al. A Cholinergic Receptor Gene (CHRM2) Affects Event-related Oscillations. Behav Genet 36, 627–639 (2006). https://doi.org/10.1007/s10519-006-9075-6

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  • DOI: https://doi.org/10.1007/s10519-006-9075-6

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