Abstract
Here I describe an Internet accessible database containing interpolated genetic map positions for 12917 marker loci. These are estimated via locally weighted linear regression (loess) from the Build 35.1 physical map position and the linkage map of Kong, X., and coworkers (2004) Am. J. Hum. Genet. 75:1143–1148. For the pseudoautosomal region, I have interpolated a male map based on the sperm typing data of Lien, S., and coworkers (2000) Am. J. Hum. Genet. 66:557–566.
Similar content being viewed by others
References
Bahlo M., Xing L., and Wilkinson C. R. (2004). HumanMSD and MouseMSD: generating genetic maps for human and murine microsatellite markers. Bioinformatics 20:3280–3283
Broman K. W., Murray J. C., Sheffield V. C., White R. L., and Weber J. L. (1998). Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am. J. Hum. Genet. 63:861–869
Collins A., Frezal J., Teague J., and Morton N. E. (1996). A metric map of humans: 23,500 loci in 850 bands. Proc. Natl. Acad. Sci. USA 93:14771–14775
Kong, A., Gudbjartsson D. F., Sainz, J. Jonsdottir G. M., Gudjonsson S. A., Richardsson B., Sigurdardottir S., Barnard J., Hallbeck B., Masson G., et al. (2002). A high-resolution recombination map of the human genome. Nat. Genet. 31:241–247
Kong X., Murphy K., Raj T., He C., White P. S., and Matise T. C. (2004). A Combined Linkage-Physical Map of the Human Genome. Am. J. Hum. Genet. 75:1143–1148
Lien S., Szyda J., Schechinger B., Rappold G., and Arnheim N. (2000). Evidence for heterogeneity in recombination in the human pseudoautosomal region: high resolution analysis by sperm typing and radiation-hybrid mapping. Am. J. Hum. Genet. 66:557–566
Loader C. (2004). locfit: Local Regression, Likelihood and Density Estimation. R package version 1.1–9. http://www.cm.bell-labs.com/stat/project/locfit/
McVean G. A., Myers S. R., Hunt S., Deloukas P., Bentley D. R., and Donnelly P. (2004) The fine-scale structure of recombination rate variation in the human genome. Science 304:581–584
Nievergelt, C. M., Smith, D. W., Kohlenberg, J. B., and Schork, N. J., (2004). Large-scale integration of human genetic and physical maps. Genome Res. 14: 1199–1205
R Development Core Team (2005). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3–900051–07–0, URL http://www.R-project.org.
Stassen H. H. and Scharfetter C. (2000) Integration of genetic maps by polynomial transformations. Am. J. Med. Genet. 96:108–113
Tapper W., Collins A., Gibson J., Maniatis N., Ennis S., and Morton N. E. (2005). A map of the human genome in linkage disequilibrium units. Proc. Natl. Acad. Sci. USA 102:11835–11839
Zhu G., Evans D. M., Duffy D. L., Montgomery G. W., Medland S. E., Gillespie N. A., Ewen K. R., Jewell M., Liew Y. W., Hayward N. K., Sturm R. A., Trent J. M., and Martin N. G. (2004). A genome scan for eye colour in 502 twin families: most variation is due to a QTL on chromosome 15q. Twin Res. 7:197–210
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Duffy, D. An Integrated Genetic Map for Linkage Analysis. Behav Genet 36, 4–6 (2006). https://doi.org/10.1007/s10519-005-9015-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10519-005-9015-x