We studied the effect of hypokinesia alone and in combination with cold exposure on HR and total cholesterol content in the blood serum of Wistar, WKY, and SHR rats. Irrespectively of the season, hypokinesia was associated with a decrease in HR, which is probably a result of reduced body needs due to deceleration of metabolic processes. A significant increase in total cholesterol was found under conditions of cold exposure combined with hypokinesia, which indicates qualitative structural rearrangement of energy metabolism under the influence of environmental factors. In winter, the increase in total cholesterol concentration was more pronounced (by 51.5%) in the group of hypertensive animals. Presumably, the increase in the serum concentration of total cholesterol under conditions of hypokinesia and cold exposure is a predictor of structural changes in the heart.
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References
Antonova EP, Ilyukha V, Sergina S. Antioxidant defense system in hibernating mammals. Printsipy Ekologii. 2015;(2):4-20. Russian,
Glukhov AV, Egorov YuV, Rosenshtaukh LV. Electrophysiological mechanisms of natural resistance of the hibernator heart to hypothermic ventricular fibrillation. Uspekhi Fiziol Nauk. 2014;45(1):3-26. Russian.
Zaripova RI, Andrianov VV, Yafarova GG, Gainutdinov KhL, Khabibrakhmanov II, Zefirov TL. Influence of hypokinezia of varying duration on the nitric oxide productions dynamics in rat’s heart, spinal cord and liver. Ross. Fiziol. Zh. 2014;100(8):926-935. Russian.
Maksimov AL, Gorbachev AL. Effects of cold training on the thyroid gland and parameters of lipid metabolism in residents of the Northeast of Russia. Fiziol. Chel. 2003;29(2):62-66. Russian.
Nepomnyashchikh LM, Lushnikova EL, Polyakov LP, Molodykh OP, Klinnikova MG, Russkikh GS, Poteryaeva ON, Nepomnyashchikh RD, Pichigin VI. Structural changes in the myocardium and serum lipid spectrum in experimental hypercholesterolemia and hypothyroidism. Bull. Exp. Biol. Med. 2013;155(5):692-696. https://doi.org/10.1007/s10517-013-2228-8
Nikitin YuP, Dushkin MI, Ragino YuI, Romashchenko AG, Voevoda MI. Some molecular biological mechanisms of atherosclerosis. Ateroskleroz. 2008;4(1):3-10. Russian.
Osadchuk LV, Gutorova NV, Ludinina AYu, Potolitsyna NN, Bojko ER. Changes in hormonal and metabolic status in men of an ethnic group Komi with overweight and obesity. Ozhirenie Metabolizm. 2013;10(2):28-32. Russian.
Panin LE. Fundamental problems of the circumpolar and the arctic medicine. Byull. Sib. Otdel. Ross. Akad. Med. Nauk. 2013;33(6):5-10. Russian.
Hasnulin VI, Gafarov VV, Voevoda MI, Artamonova MV. Mortality from diseases of the cardiovascular system based on the average air temperature and residence geographical latitudes in Russia. Mezhdunarod. Zh. Priklad. Fundament. Issled. 2015;(6-2):255-259. Russian.
Khoch NS, Gratsianova AD. Changes in the morphofunctional state of the thyroid gland with a combined effect on the body of hypokinesia and cold. Vestn. Tomsk. Gos. Ped. Univer. 2000;(9):51-55. Russian.
Shmakov DN, Nuzhny VP, Kibler NA. Combined Effects of Hypokinesia and Ambient Temperature on Heart Remodeling in Normotensive and Hypertensive Rats. Bull. Exp. Biol. Med. 2019;167(6):720-722. https://doi.org/10.1007/s10517-019-04607-9
Madamanchi NR, Runge MS. Mitochondrial dysfunction in atherosclerosis. Circ. Res. 2007;100(4):460-473.
Takeuchi T, Nemoto K, Takahashi O, Urayama KY, Deshpande GA, Izumo H. Comparison of cardiovascular disease risk associated with 3 lipid measures in Japanese adults. J. Clin. Lipidol. 2014;8(5):501-509.
Wende AR, Symons JD, Abel ED. Mechanisms of lipotoxicity in the cardiovascular system. Curr. Hypertens. Rep. 2012;14(6):517-531.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 6, pp. 677-681, June, 2020
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Shmakov, D.N., Nuzhny, V.P., Kibler, N.A. et al. Changes in Total Cholesterol and Heart Rate in Normotensive and Hypertensive Rats under Combined Influence of Cold Exposure and Hypokinesia. Bull Exp Biol Med 169, 738–741 (2020). https://doi.org/10.1007/s10517-020-04968-6
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DOI: https://doi.org/10.1007/s10517-020-04968-6