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Development of Proliferative Response of Thymic Lymphocytes to T-Cell Mitogen in Rats Exposed to Endocrine Disrupter DDT during Ontogeny

  • IMMUNOLOGY AND MICROBIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the formation of proliferative response of thymic lymphocytes to T-cell mitogen in rats exposed to endocrine disrupter DDT during prenatal and postnatal ontogeny. Developmental exposure to the endocrine disruptor was found to attenuate proliferative response during puberty and adulthood due to maintenance of higher proliferation rate of thymic lymphocytes in comparison with age-matched controls. Insufficient proliferative response to mitogens in rats developmentally exposed to the endocrine disrupter increases the risk of impairment of cell-mediated reactions of adaptive immunity.

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Authors and Affiliations

  1. Laboratory of Endocrine System Development, Research Institute of Human Morphology, Moscow, Russia

    S. S. Obernikhin, N. V. Yaglova, S. V. Nazimova, E. P. Timokhina & V. V. Yaglov

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  1. S. S. Obernikhin
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  2. N. V. Yaglova
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  3. S. V. Nazimova
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  4. E. P. Timokhina
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  5. V. V. Yaglov
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Corresponding author

Correspondence to N. V. Yaglova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 1, pp. 66-69, January, 2020

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Obernikhin, S.S., Yaglova, N.V., Nazimova, S.V. et al. Development of Proliferative Response of Thymic Lymphocytes to T-Cell Mitogen in Rats Exposed to Endocrine Disrupter DDT during Ontogeny. Bull Exp Biol Med 169, 60–62 (2020). https://doi.org/10.1007/s10517-020-04824-7

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  • DOI: https://doi.org/10.1007/s10517-020-04824-7

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