Skip to main content
SpringerLink
Log in

Effect of VNTR Polymorphism of the AS3MT Gene and Obstetrical Complications on the Severity of Schizophrenia

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The role of the VNTR polymorphism of the AS3MT gene in determining the clinical features of schizophrenia and schizophrenic spectrum disorders was studied. The analysis included 670 individuals. We found no differences in PANSS scores for positive, negative, and common psychopathological symptoms between the carriers of different genotypes. The interaction of the studied polymorphism and obstetrical complications as an environmental factor was found. The genotype-environment interactions were identified for one of the characteristics reflecting the severity of schizophrenia: the level of negative symptoms. Women with the V2/V2 genotype, who have obstetrical complications, showed significantly higher negative symptoms scores, which was associated with a poor prognosis of the disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Berezantsev AYu. Gender differences in the clinical manifestations and course of schizophrenia: neurobiological and psychosocial aspects. Nevrologiya, Neiropsikhiatriya, Psikhosomatika. 2017;9(4):77-81. Russian.

    Article  Google Scholar 

  2. Evtushenko ID, Krasnonosenkikh TP, Balashov PP. Mental diseases associated with pregnancy and labor courses. Byull. Sib. Otdel. Ross. Akad. Med. Nauk. 2003;23(2):9-11. Russian.

    Google Scholar 

  3. Khamenka NV. Genetic and environmental factors in the development of schizophrenia. Med. Zh. 2012;(2):15-18. Russian.

    Google Scholar 

  4. Dieset I, Andreassen OA, Haukvik UK. Somatic comorbidity in schizophrenia: some possible biological mechanisms across the life span. Schizophr. Bull. 2016;42(6):1316-1319.

    Article  Google Scholar 

  5. Duarte RRR, Troakes C, Nolan M, Srivastava DP, Murray RM, Bray NJ. Genome-wide significant schizophrenia risk variation on chromosome 10q24 Is associated with altered cis-regulation of BORCS7, AS3MT, and NT5C2 in the human brain. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2016;171(6):806-814.

    CAS  Google Scholar 

  6. Kunugi H, Nanko S, Murray RM. Obstetric complications and schizophrenia: prenatal underdevelopment and subsequent neurodevelopmental impairment. Br. J. Psychiatry Supp. 2001;40:s25-s29.

    Article  CAS  Google Scholar 

  7. Li L, Chang H, Peng T, Li M, Xiao X. Evidence of AS3MTd2d3-associated variants within 10q24.32-33 in the genetic risk of major affective disorders. Mol. Neuropsychiatry. 2017;2(4):213-218.

    Google Scholar 

  8. Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth JG, Hoeppner DJ, Wei H, Hyde TM, McKay R, Kleinman JE, Weinberger DR. A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus. Nat. Med. 2016;22(6):649-656.

    CAS  Google Scholar 

  9. Riley B, Kendler KS. Molecular genetic studies of schizophrenia. Eur. J. Hum. Genet. 2006;14(6):669-680.

    Article  CAS  Google Scholar 

  10. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014;511:421-427.

    Article  Google Scholar 

  11. Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietiläinen OP, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Børglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Böttcher Y, Olesen J, Breuer R, Möller HJ, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I, Réthelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Masson G, Gulcher JR, Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S, Franke B, Strengman E, Kiemeney LA; Genetic Risk and Outcome in Psychosis (GROUP), Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de Frutos R, Bramon E, Vassos E, Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Yoon JL, Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A, Arango C, Costas J, Jönsson EG, Terenius L, Agartz I, Petursson H, Nöthen MM, Rietschel M, Matthews PM, Muglia P, Peltonen L, St Clair D, Goldstein DB, Stefansson K, Collier DA. Common variants conferring risk of schizophrenia. Nature. 2009;460:744-747.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Сenter of Mental Health, Moscow, Russia

    G. I. Korovaitseva, M. V. Gabaeva, O. A. Yunilainen & V. E. Golimbet

Authors
  1. G. I. Korovaitseva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. V. Gabaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. A. Yunilainen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. E. Golimbet
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. I. Korovaitseva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 7, pp. 96-99, July, 2019

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Korovaitseva, G.I., Gabaeva, M.V., Yunilainen, O.A. et al. Effect of VNTR Polymorphism of the AS3MT Gene and Obstetrical Complications on the Severity of Schizophrenia. Bull Exp Biol Med 168, 84–86 (2019). https://doi.org/10.1007/s10517-019-04653-3

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-019-04653-3

Key Words

Search

Navigation