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Gene Polymorphism of Xenobiotic Biotransformation Enzymes in Patients with Classical Ph-Negative Myeloproliferative Neoplasms

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The correlation of gene polymorphisms rs4025935 (large deletion), rs1695 (313A>G), rs71748309 (large deletion), and rs1800566 (609C>T) of GSTM1, GSTT1, and NQO1 genes encoding glutathione-S-transferases (GST) M1, P1, and T1 and NADPH-quinone oxidoreductase with the risk of development of classical Ph-negative myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, and primary myelofibrosis) was studied in the Caucasian ethnicity population of Vyatka region of the Russian Federation. It was found that NQO1*609T allele, NQO1*609T genotypes, and homozygous carriage of a deletion (null) allele of GSTT1 gene are associated with the risk of development of myeloproliferative neoplasms (OR=1.29, 95%CI=1.02-1.64, p=0.04; OR=1.39, 95%CI=1.04-1.85, p=0.03; and OR=1.48, 95%CI=1.03-2.12, p=0.03, respectively). However, no influence of GSTM1 and GSTP1 gene polymorphisms on the risk of development of myeloproliferative disorders was registered.

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Authors and Affiliations

  1. Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of the Russian Federation, Kirov, Russia

    V. A. Ovsepyan, E. V. Tregubova, A. S. Luchinin & N. V. Minaeva

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  1. V. A. Ovsepyan
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  2. E. V. Tregubova
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  3. A. S. Luchinin
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  4. N. V. Minaeva
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Correspondence to V. A. Ovsepyan.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 6, pp. 726-730, June, 2019

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Ovsepyan, V.A., Tregubova, E.V., Luchinin, A.S. et al. Gene Polymorphism of Xenobiotic Biotransformation Enzymes in Patients with Classical Ph-Negative Myeloproliferative Neoplasms. Bull Exp Biol Med 167, 767–770 (2019). https://doi.org/10.1007/s10517-019-04619-5

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  • DOI: https://doi.org/10.1007/s10517-019-04619-5

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