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Analysis of Anti-Glycan IgG and IgM Antibodies in Colorectal Cancer

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Bulletin of Experimental Biology and Medicine Aims and scope

We propose an approach that allows simultaneous determination of the levels of M and G isotypes of antibodies to the panel of glycans using microarrays. The level of IgG antibodies to 3’-O-su-Lea glycan detects patients with colorectal cancer with a sensitivity of 69.77% and specificity of 62.75%. The percentage of correctly classified colorectal cancer patients with the use of a combination of two markers IgM antibodies to glycans 3’-sialyl-TF and 3’-O-su-Lea is as high as 74.23%. The levels of IgM antibodies to 3’-O-su-Lea glycan differ significantly in patients with and without regional metastases. The levels of some of antiglycan IgM or IgG antibodies differed significantly in patients with tumors of different location and differentiation.

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Authors and Affiliations

  1. V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

    A. A. Tikhonov, E. N. Savvateeva, V. V. Maslennikov & A. Yu. Rubina

  2. P. A. Hertsen Moscow Research Oncological Institute, Affiliated Branch of National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Moscow, Russia

    M. A. Chernichenko & D. V. Sidorov

  3. N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia

    N. E. Kushlinskii

Authors
  1. A. A. Tikhonov
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  2. E. N. Savvateeva
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  3. M. A. Chernichenko
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  4. V. V. Maslennikov
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  5. D. V. Sidorov
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  6. A. Yu. Rubina
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  7. N. E. Kushlinskii
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Corresponding author

Correspondence to A. A. Tikhonov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 10, pp. 485-490, October, 2018

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Tikhonov, A.A., Savvateeva, E.N., Chernichenko, M.A. et al. Analysis of Anti-Glycan IgG and IgM Antibodies in Colorectal Cancer. Bull Exp Biol Med 166, 489–493 (2019). https://doi.org/10.1007/s10517-019-04379-2

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  • DOI: https://doi.org/10.1007/s10517-019-04379-2

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