The data on cancer stem cell surface molecular markers of 27 most common cancer diseases were analyzed using natural language processing and data mining techniques. As a source, 8933 full-text open-access English-language scientific articles available on the Internet were used. Text mining was based on searching for three entities within one sentence, namely a tumor name, a phrase “cancer stem cells” or its synonym, and a name of differentiation cluster molecule. As a result, a list of surface molecular markers was formed that included markers most frequently mentioned in the context of certain tumor diseases and used in studies of human and animal tumor cells. Based on similarity of the associated markers, the tumors were divided into five groups.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kim YS, Kaidina AM, Chiang JH, Yarygin KN, Lupatov AYu. Molecular markers of cancer stem cells verified in vivo. Biomed. Khimiya. 2016;62(3):228-238. Russian.
Abdullah LN, Chow EK. Mechanisms of chemoresistance in cancer stem cells. Clin. Transl. Med. 2013;2(1):3. doi: https://doi.org/10.1186/2001-1326-2-3.
Fang X, Zheng P, Tang J, Liu Y. CD24: from A to Z. Cell. Mol. Immunol. 2010;7(2):100-103.
Kim YS, Kaidina AM, Yarygin KN, Lupatov AY, Chiang JH. Cancer stem cell molecular markers verified in vivo. Biochemistry (Moscow). Suppl. Ser. B. Biomed. Chem. 2017;11(1):43-54.
Nielsen JS, McNagny KM. Novel functions of the CD34 family. J. Cell Sci. 2008;121(Pt 22):3683-3692.
Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001;414:105-111.
Wei CH, Peng Y, Leaman R, Davis AP, Mattingly CJ, Li J, Wiegers TC, Lu Z. Assessing the state of the art in biomedical relation extraction: overview of the BioCreative V chemicaldisease relation (CDR) task. Database (Oxford). 2016;2016. pii: baw032. doi: https://doi.org/10.1093/database/baw032.
Williams K, Motiani K, Giridhar PV, Kasper S. CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches. Exp. Biol. Med. (Maywood). 2013;238(3):324-338.
Yin AH, Miraglia S, Zanjani ED, Almeida-Porada G, Ogawa M, Leary AG, Olweus J, Kearney J, Buck DW. AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood. 1997;90(12):5002-5012.
Yu Y, Ramena G, Elble RC. The role of cancer stem cells in relapse of solid tumors. Front. Biosci. (Elite Ed). 2012;4:1528-1541.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 3, pp. 157-163, September, 2018
Rights and permissions
About this article
Cite this article
Suvorov, R.E., Kim, Y.S., Gisina, A.M. et al. Surface Molecular Markers of Cancer Stem Cells: Computation Analysis of Full-Text Scientific Articles. Bull Exp Biol Med 166, 135–140 (2018). https://doi.org/10.1007/s10517-018-4302-8
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-018-4302-8