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Therapeutic Potential of Biomedical Cell Product in DSS-Induced Inflammation in the Small Intestine of C57Bl/6J Mice

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of intravenous administration of biomedical cell product (bone marrow mesenchymal stem cells and media conditioned by these cells) on histological picture of the small intestine in mice with DSS-induced inflammation. It was shown that biomedical cell product promoted recovery of the intestinal mucosa in DSS-induced inflammation.

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References

  1. Banerjee A, Bizzaro D, Burra P, Di Liddo R, Pathak S, Arcidiacono D, Cappon A, Bo P, Conconi MT, Crescenzi M, Pinna CM, Parnigotto PP, Alison MR, Sturniolo GC, D’Inca R, Russo FP. Umbilical cord mesenchymal stem cells modulate dextran sulfate sodium induced acute colitis in immunodeficient mice. Stem Cell Res. Ther. 2015;6:79. doi:https://doi.org/10.1186/s13287-015-0073-6.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. da Costa Gonçalves F, Grings M, Nunes NS, Pinto FO, Garcez TN, Visioli F, Leipnitz G, Paz AH. Antioxidant properties of mesenchymal stem cells against oxidative stress in a murine model of colitis. Biotechnol. Lett. 2017;39(4):613-622.

    Article  PubMed  CAS  Google Scholar 

  3. Ginzel M, Feng X, Kuebler JF, Klemann C, Yu Y, von Wasielewski R, Park JK, Hornef MW, Vieten G, Ure BM, Kaussen T, Gosemann JH, Mayer S, Suttkus A, Lacher M. Dextran sodium sulfate (DSS) induces necrotizing enterocolitis-like lesions in neonatal mice. PLoS One. 2017;12(8):e0182732. doi: https://doi.org/10.1371/journal.pone.0182732.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Gracz AD, Magness ST. Defining hierarchies of stemness in the intestine: evidence from biomarkers and regulatory pathways. Am. J. Physiol. Gastrointest. Liver Physiol. 2014;307(3):G260-G273.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Parry L, Young M, El Marjou F, Clarke AR. Evidence for a crucial role of paneth cells in mediating the intestinal response to injury. Stem Cells. 2013;31(4):776-785.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Parry L, Young M, El Marjou F, Clarke AR. Protocols for analyzing the role of paneth cells in regenerating the murine intestine using conditional cre-lox mouse models. J. Vis. Exp. 2015. N 105. doi: https://doi.org/10.3791/53429.

  7. Perşe M, Cerar A. Dextran sodium sulphate colitis mouse model: traps and tricks. J. Biomed. Biotechnol. 2012;2012. doi:https://doi.org/10.1155/2012/718617.

  8. Pouya S, Heidari M, Baghaei K, Asadzadeh Aghdaei H, Moradi A, Namaki S, Zali MR, Hashemi SM. Study the effects of mesenchymal stem cell conditioned medium injection in mouse model of acute colitis. Int Immunopharmacol. 2018;54:86-94.

    Article  PubMed  CAS  Google Scholar 

  9. Song JY, Kang HJ, Hong JS, Kim CJ, Shim JY, Lee CW, Choi J. Umbilical cord-derived mesenchymal stem cell extracts reduce colitis in mice by re-polarizing intestinal macrophages. Sci. Rep. 2017;7(1):9412. doi: https://doi.org/10.1038/s41598-017-09827-5.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    A. P. Lykov, O. V. Poveshchenko, N. A. Bondarenko, M. A. Surovtseva, I. I. Kim & N. P. Bgatova

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  1. A. P. Lykov
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  2. O. V. Poveshchenko
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  3. N. A. Bondarenko
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  4. M. A. Surovtseva
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  5. I. I. Kim
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  6. N. P. Bgatova
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Corresponding author

Correspondence to A. P. Lykov.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 121-125, June, 2018

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Lykov, A.P., Poveshchenko, O.V., Bondarenko, N.A. et al. Therapeutic Potential of Biomedical Cell Product in DSS-Induced Inflammation in the Small Intestine of C57Bl/6J Mice. Bull Exp Biol Med 165, 576–580 (2018). https://doi.org/10.1007/s10517-018-4216-5

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  • DOI: https://doi.org/10.1007/s10517-018-4216-5

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