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Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes

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Bulletin of Experimental Biology and Medicine Aims and scope

Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug.

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Authors and Affiliations

  1. BioClinicum Center, Moscow, Russia

    S. V. Nikulin, M. P. Raigorodskaya, A. A. Poloznikov & G. S. Zakharova

  2. Moscow Institute of Physics and Technology (MIPT), Moscow, Russia

    S. V. Nikulin

  3. P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation, Moscow, Russia

    K. A. Fomicheva, B. Ya. Alekseev & M. Yu. Shkurnikov

  4. University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    U. Schumacher, D. Wicklein, C. Stürken & K. Riecken

Authors
  1. S. V. Nikulin
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  2. M. P. Raigorodskaya
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  3. A. A. Poloznikov
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  4. G. S. Zakharova
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  5. U. Schumacher
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  6. D. Wicklein
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  7. C. Stürken
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  8. K. Riecken
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  9. K. A. Fomicheva
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  10. B. Ya. Alekseev
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  11. M. Yu. Shkurnikov
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Corresponding author

Correspondence to B. Ya. Alekseev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 11, pp. 605-610, November, 2017

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Nikulin, S.V., Raigorodskaya, M.P., Poloznikov, A.A. et al. Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes. Bull Exp Biol Med 164, 650–654 (2018). https://doi.org/10.1007/s10517-018-4051-8

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  • DOI: https://doi.org/10.1007/s10517-018-4051-8

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