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Five Hypermethylated MicroRNA Genes as Potential Markers of Ovarian Cancer

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Bulletin of Experimental Biology and Medicine Aims and scope

MicroRNA and methylation are important epigenetic mechanisms in the pathogenesis of cancer. The role of a group of microRNA hypermethylated genes in the pathogenesis of ovarian cancer was studied and their diagnostic and prognostic potential was evaluated. Studies on a representative sample of 54 ovarian cancer specimens with the use of methyl-specific PCR resulted in detection of five microRNA genes (MIR-9-1, MIR-9-3, MIR-107, MIR-1258, and MIR-130b) methylated in the majority of tumor specimens in comparison with paired specimens of histologically intact tissue (37-57% vs. 4-9%, p<0.01). Methylation of three genes (MIR-9-1, MIR-9-3, and MIR-130b) was significantly (p≤0.05) associated with the parameters of ovarian cancer progress (clinical stage, differentiation degree, tumor size, and presence of metastases). These findings attest to oncosuppressive role of the studied microRNA genes (MIR-9-1, MIR-9-3, MIR-107, MIR-1258, and MIR-130b) in the pathogenesis and progress of ovarian cancer and indicated their prognostic potential.

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Authors and Affiliations

  1. Research Institute of Pathology and Pathophysiology, Moscow, Russia

    E. A. Braga, V. I. Loginov, A. M. Burdennyi, E. A. Filippova, I. V. Pronina & S. V. Kurevlev

  2. Research Centre of Medical Genetics, Moscow, Russia

    E. A. Braga & V. I. Loginov

  3. N. N. Blokhin Russian Cancer Research Center, the Ministry of Health of the Russian Federation, Moscow, Russia

    T. P. Kazubskaya, D. N. Kushlinskii, D. O. Utkin, V. D. Ermilova & N. E. Kushlinskii

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  1. E. A. Braga
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  2. V. I. Loginov
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  3. A. M. Burdennyi
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  4. E. A. Filippova
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  5. I. V. Pronina
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  6. S. V. Kurevlev
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  7. T. P. Kazubskaya
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  8. D. N. Kushlinskii
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  9. D. O. Utkin
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  10. V. D. Ermilova
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  11. N. E. Kushlinskii
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Corresponding author

Correspondence to E. A. Braga.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 9, pp. 335-340, September, 2017

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Braga, E.A., Loginov, V.I., Burdennyi, A.M. et al. Five Hypermethylated MicroRNA Genes as Potential Markers of Ovarian Cancer. Bull Exp Biol Med 164, 351–355 (2018). https://doi.org/10.1007/s10517-018-3988-y

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  • DOI: https://doi.org/10.1007/s10517-018-3988-y

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