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Gene TNF Polymorphism -308G>A (rs1800629) and Its Relationship with the Efficiency of Ursodeoxycholic Acid Therapy in Patients with Nonalcoholic Stetohepatitis

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Bulletin of Experimental Biology and Medicine Aims and scope

Association of TNF gene polymorphism -308G>A with the development of nonalcoholic steatohepatitis in the Russian population was revealed. Carriers of allele A of the TNF gene marker -308G>A have significantly higher risk of nonalcoholic steatohepatitis development: OR=1.69 (1.05; 2.71). Allele A carriage by this marker predicts an increase in the basal HDL level and a decrease in LDL and IL-10 levels in the blood of healthy subjects. Patients with nonalcoholic steatohepatitis, differing by the TNF gene -308G>A marker genotype, differ by the time course of the markers of hepatocellular damage (ALT, AST), activity of hepatocyte apoptosis (tissue polypeptide-specific antigen), and activation of specific humoral immunity (γ-globulin) in response to therapy with ursodeoxycholic acid in a dose of 10-15 mg/kg over 4-6 weeks. Carriers of allele A of the TNF gene polymorphic marker -308G>A are more sensitive to ursodeoxycholic acid therapy than carriers of GG genotype.

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Authors and Affiliations

  1. Institute of Biology, Karelian Research Center, Russian Academy of Sciences, Moscow, Russia

    I. V. Kurbatova & L. V. Topchieva

  2. Petrozavodsk State University, Petrozavodsk, Republic of Karelia, Russia

    O. P. Dudanova

Authors
  1. I. V. Kurbatova
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  2. L. V. Topchieva
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  3. O. P. Dudanova
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Correspondence to I. V. Kurbatova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 8, pp. 209-214, August, 2017

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Kurbatova, I.V., Topchieva, L.V. & Dudanova, O.P. Gene TNF Polymorphism -308G>A (rs1800629) and Its Relationship with the Efficiency of Ursodeoxycholic Acid Therapy in Patients with Nonalcoholic Stetohepatitis. Bull Exp Biol Med 164, 181–185 (2017). https://doi.org/10.1007/s10517-017-3953-1

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  • DOI: https://doi.org/10.1007/s10517-017-3953-1

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