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Study of Proliferative Activity of Vaginal Epithelium in Women with Stress Urinary Incontinence Treated by Er:YAG Laser

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The expression of Ki-67 proliferation marker was studied in vaginal biopsy specimens from women with stress urinary incontinence treated using a Fotona nonablative erbium laser. Cells expressing Ki-67 were located in all cases in the parabasal and basal levels of stratified squamous epithelium, the index of labeled nuclei before Er:YAG laser exposure was 19.05±2.86%. After 1-2 months of laser therapy, the index of labeled nuclei in the epithelium increased significantly and reached 31.79±2.25%. These changes were interpreted as a result of epithelial-stromal interactions. Presumably, the increase in proliferative activity of the vaginal epithelium after exposure to Er:YAG laser was due to the presence of an appreciable level of synthetically active fibroblasts in the subepithelial stroma.

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Authors and Affiliations

  1. Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia

    G. A. Lapii, A. Yu. Yakovleva & E. L. Lushnikova

  2. Altai State Medical University, Barnaul, Russia

    A. I. Neimark

Authors
  1. G. A. Lapii
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  2. A. Yu. Yakovleva
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  3. A. I. Neimark
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  4. E. L. Lushnikova
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Correspondence to G. A. Lapii.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 2, pp. 251-255, February, 2017

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Lapii, G.A., Yakovleva, A.Y., Neimark, A.I. et al. Study of Proliferative Activity of Vaginal Epithelium in Women with Stress Urinary Incontinence Treated by Er:YAG Laser. Bull Exp Biol Med 163, 280–283 (2017). https://doi.org/10.1007/s10517-017-3784-0

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  • DOI: https://doi.org/10.1007/s10517-017-3784-0

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