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Role of ATP-Sensitive K+ Channels in Myocardial Infarct Size-Limiting Effect of Chronic Continuous Normobaric Hypoxia

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The role of KATP channels in myocardial infarct size-limiting effect of chronic continuous normobaric hypoxia was examined in a rat model based on a 20-min coronary occlusion and subsequent 3-h reperfusion. Rats were adapted to normobaric hypoxia (12% O2) for 21 days. This hypoxia produced a pronounced infarct size-limiting effect, which had been prevented by 0.3 mg/kg glibenclamide, a non-selective inhibitor of entire pool of KATP channels, or 5 mg/kg 5-hydroxydecanoate, an inhibitor of mitochondrial KATP channels. The study highlighted the important role of mitochondrial KATP channels in myocardial infarct size-limiting effect of chronic normobaric hypoxia.

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Authors and Affiliations

  1. Research Institute of Cardiology, Tomsk Research Medical Center, Tomsk, Russia

    Yu. B. Lishmanov, N. V. Naryzhnaya, S. Yu. Tsibul’nikov & L. N. Maslov

  2. National Research Tomsk Polytechnic University, Tomsk, Russia

    Yu. B. Lishmanov & S. Yu. Tsibul’nikov

  3. Liaoning Medical College, Jinzhou City, Liaoning Province, China

    H. Wang

Authors
  1. Yu. B. Lishmanov
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  2. N. V. Naryzhnaya
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  3. S. Yu. Tsibul’nikov
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  4. H. Wang
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  5. L. N. Maslov
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Corresponding author

Correspondence to N. V. Naryzhnaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 1, pp. 28-31, January, 2017

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Lishmanov, Y.B., Naryzhnaya, N.V., Tsibul’nikov, S.Y. et al. Role of ATP-Sensitive K+ Channels in Myocardial Infarct Size-Limiting Effect of Chronic Continuous Normobaric Hypoxia. Bull Exp Biol Med 163, 22–24 (2017). https://doi.org/10.1007/s10517-017-3728-8

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  • DOI: https://doi.org/10.1007/s10517-017-3728-8

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