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Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β2 in Rat Bone Tissue after Bone Fracture and Placement of Titanium Implants with Bioactive Bioresorbable Coatings

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Bulletin of Experimental Biology and Medicine Aims and scope

The study established enhanced expression of vascular endothelial growth factor (VEGF) in the subpopulation of osteoblasts located in the regeneration region of femoral bone fracture near the titanium implants with bioactive calcium phosphate and hydroxyapatite coatings and suppressed activity of transforming growth factor-β2 (TGF-β2) in chondroblasts during the two weeks after surgery. In the delayed posttraumatic period, the distribution of TGF-β2 inversely related to its maximal activity. The data revealed the up-regulating effect of bioresorbable coatings on expression of VEGF and TGF-β2 and their implication in the control over various stages of reparative osteogenesis.

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Authors and Affiliations

  1. Department of Histology, Cytology, and Embryology, Pacific State Medical University, Vladivostok, Russia

    S. G. Kalinichenko, N. Yu. Matveeva & R. E. Kostiv

  2. Laboratory of Biomedical Composition Coatings, Institute of Chemistry, Far-East Division of Russian Academy of Sciences, Vladivostok, Russia

    S. G. Kalinichenko, N. Yu. Matveeva & A. V. Puz’

Authors
  1. S. G. Kalinichenko
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  2. N. Yu. Matveeva
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  3. R. E. Kostiv
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  4. A. V. Puz’
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Corresponding author

Correspondence to S. G. Kalinichenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 11, pp. 626-631, November, 2016

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Kalinichenko, S.G., Matveeva, N.Y., Kostiv, R.E. et al. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β2 in Rat Bone Tissue after Bone Fracture and Placement of Titanium Implants with Bioactive Bioresorbable Coatings. Bull Exp Biol Med 162, 671–675 (2017). https://doi.org/10.1007/s10517-017-3684-3

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  • DOI: https://doi.org/10.1007/s10517-017-3684-3

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