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Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride

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Hepatoprotective properties of a new pyrimidine derivative — L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, synthesized on the basis Xymedon, were assessed in white rats exposed to CCl4. The compound under study administered prior to exposure to CCl4 reduced the deviation of biochemical parameters from reference values and severity of structural and morphological changes in liver, when compared to the control. Hepatoprotective properties of the studied compound were more pronounced than those of Xymedon.

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Authors and Affiliations

  1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia

    A. B. Vyshtakalyuk, N. G. Nazarov, V. V. Zobov, O. A. Minnekhanova, V. E. Semenov, I. V. Galyametdinova, G. V. Cherepnev & V. S. Reznik

  2. Medical Unit of Kazan (Volga Region) Federal University, Kazan, Russia

    G. V. Cherepnev

  3. Kazan (Volga Region) Federal University, Kazan, Russia

    N. G. Nazarov, V. V. Zobov & S. R. Abdulkhakov

Authors
  1. A. B. Vyshtakalyuk
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  2. N. G. Nazarov
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  3. V. V. Zobov
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  4. S. R. Abdulkhakov
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  5. O. A. Minnekhanova
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  6. V. E. Semenov
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  7. I. V. Galyametdinova
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  8. G. V. Cherepnev
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  9. V. S. Reznik
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Corresponding author

Correspondence to A. B. Vyshtakalyuk.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 9, pp. 322-325, September, 2016

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Vyshtakalyuk, A.B., Nazarov, N.G., Zobov, V.V. et al. Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride. Bull Exp Biol Med 162, 340–342 (2017). https://doi.org/10.1007/s10517-017-3610-8

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  • DOI: https://doi.org/10.1007/s10517-017-3610-8

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