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Neuroprotective Effect of Antioxidants and Moderate Hypoxia as Combined Preconditioning in Cerebral Ischemia

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We studied combined effect of moderate hypoxia and compounds pQ-4, pQ-915, pQ-1032, and pQ-1104 on neurological deficit and survival of rats after bilateral ligation of common carotid arteries. Preconditioning including moderate hypoxia and treatment with compound pQ-4 produced a neuroprotective effect and increased animal survival during the early (by 51%) and late (by 33.5%) periods of modeled ischemia and reduced neurological deficit (by 50% and 41%, respectively). Moreover, this combination of preconditioning factors prevented postischemic excessive activation of free radical oxidation in brain hemispheres and blood serum.

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Authors and Affiliations

  1. Department of Pharmacology, Smolensk State Medical University, Smolensk, Russia

    O. S. Levchenkova, V. E. Novikov, E. A. Parfenov & K. N. Kulagin

Authors
  1. O. S. Levchenkova
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  2. V. E. Novikov
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  3. E. A. Parfenov
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  4. K. N. Kulagin
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Corresponding author

Correspondence to O. S. Levchenkova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 8, pp. 173-177, August, 2016

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Levchenkova, O.S., Novikov, V.E., Parfenov, E.A. et al. Neuroprotective Effect of Antioxidants and Moderate Hypoxia as Combined Preconditioning in Cerebral Ischemia. Bull Exp Biol Med 162, 211–214 (2016). https://doi.org/10.1007/s10517-016-3578-9

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  • DOI: https://doi.org/10.1007/s10517-016-3578-9

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