We studied the possibility of preventing disturbances caused by administration of low doses of toxicants by adaptation to interval hypoxia and hyperoxia. The preventive protective effect of adaptation to hypoxia–hyperoxia manifested in suppression of free radical oxidation, decrease in the levels of HIF-1α and inducible HOx-1, and improvement of tolerance to physical exercises.
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L. I. Andreeva, A. A. Boikova, and B. A. Margulis, Estestv. Nauki Gumanizm, 3, No. 4, 12-15 (2006).
V. M. Boev, N. N. Vereschchagin, M. A. Skachkova, et al., Human Ecology in Urbanized and Rural Areas [in Russian], Eds. N. N. Vereschchagin, and V. M. Boev, Orenburg, 392 (2003).
E. V. Ermolina, A. A. Stadnikov, I. V. Mikhailova, and A. I. Smolyagin, Izv. Samarsk. Nauch. Tsentra Ross. Akad. Nauk, 14, No. 5-2, 444-447 (2012).
Yu. V. Arkhipenko, T. G. Sazontova, O. S. Glazachev, and V. I. Platonenko, Patent RF No. 2289432. The Method of Enhancement of Non-Specific Adaptation Abilities of Humans Based on Usage of Hypoxic-Hyperoxic Gas Mixtures,Byull., No. 35, December 20, 2006.
A. E. Platonov, Statistical Analysis in Medicine and Biology: Problems, Terminology, Logics, and Computer Methods [in Russian], Moscow (2000).
T. G. Sazontova, and Yu. V. Arkhipenko, Ross. Fiziol. Zh., 91, No. 6, 636-655 (2005).
S. V. Timoshnikova, N. V. Sharapova, I. V. Mikhailova, et al., Vestn. Orenburgsk. Univer., No. 10, 132-133 (2004).
V. V. Utenin, A. A. Stadnikov, and V. M. Boev, Vestn. Orenburgsk. Univer., No. 5, 10-16 (2002).
G. Barreto, D. Madureira, F. Capani, et al., Environ. Mol. Mutagen., 50, No. 9, 771-780 (2009).
D. A. Dickinson, and H. J. Forman, Biochem. Pharmacol., 64, Nos. 5-6, 1019-1026 (2002).
I. Fridovich, Anticancer Agents Med. Chem., 11, No. 2, 175- 177 (2011).
K. Kikugawa, T. Kojima, S. Yamaki, and H. Kosugi, Analyt. Biochem., 202, No. 2, 249-255 (1992).
C. R. Myers, Free Radic. Biol. Med., 52, No. 10, 2091-2107 (2012).
T. G. Sazontova, and Y. V. Arkhipenko, Intermittent Hypoxia: from Molecular Mechanisms to Clinical Applications, Eds. L. Xi and T. V. Serebrovskaya, New York, 2009, pp. 147-187.
M. Singh, P. Thomas, D. Shukla, et al., Appl. Biochem. Biotechnol., 169, No. 8, 2405-2419 (2013).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 9, pp. 284-288, September, 2015
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Sazontova, T.G., Stryapko, N.V. & Arkhipenko, Y.V. Addition of Hyperoxic Component to Adaptation to Hypoxia Prevents Impairments Induced by Low Doses of Toxicants (Free Radical Oxidation and Proteins of HSP Family). Bull Exp Biol Med 160, 304–307 (2016). https://doi.org/10.1007/s10517-016-3157-0
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DOI: https://doi.org/10.1007/s10517-016-3157-0