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Effect of hrWnt7a on Human Retinal Pigment Epithelial Cells In Vitro

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Bulletin of Experimental Biology and Medicine Aims and scope

Human recombinant protein Wnt7a (hrWnt7a) inhibits cell proliferative activity and triggers cell polarization. Although cell polarization process was maintained only over a short time, probably via microenvironmental stimuli, hrWnt7a is involved in the transformation of the retinal pigment epithelium. Analysis of Wnt signaling pathway and its regulation will help to understand the processes in retinal pigment epithelial cells under pathological conditions, which can be useful in developing new generation drugs.

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Authors and Affiliations

  1. N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia

    A. V. Kuznetsova, A. M. Kurinov & M. A. Aleksandrova

  2. Helmholtz Moscow Research Institute of Eye Diseases, Moscow, Russia

    E. V. Chentsova & P. V. Makarov

  3. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

    M. A. Aleksandrova

Authors
  1. A. V. Kuznetsova
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  2. A. M. Kurinov
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  3. E. V. Chentsova
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  4. P. V. Makarov
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  5. M. A. Aleksandrova
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Corresponding author

Correspondence to A. V. Kuznetsova.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 78-84, April, 2015

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Kuznetsova, A.V., Kurinov, A.M., Chentsova, E.V. et al. Effect of hrWnt7a on Human Retinal Pigment Epithelial Cells In Vitro . Bull Exp Biol Med 159, 534–540 (2015). https://doi.org/10.1007/s10517-015-3010-x

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  • DOI: https://doi.org/10.1007/s10517-015-3010-x

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