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Characteristics of Mononuclear Extracellular Traps in the Offspring of Female Rats with Drug-Induced Hepatitis

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of experimental tetracycline-induced liver injury in mothers on the capacity of macrophages from various compartments to form traps and on activity of extracellular macrophage traps in the offspring. Trap-forming capacity was evaluated by the number of traps. We found reduction in the number and suppression of activity of the macrophage extracellular traps in the offspring of females with experimental liver injury. The findings suggest that mothers with drug-induced liver injury produce physiologically immature offspring with reduced unspecific resistance.

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Authors and Affiliations

  1. South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia

    G. V. Bryukhin

  2. Chelyabinsk State University, Chelyabinsk, Russia

    A. V. Shopova

Authors
  1. G. V. Bryukhin
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  2. A. V. Shopova
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Corresponding author

Correspondence to A. V. Shopova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 4, pp. 423–425, April, 2015

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Bryukhin, G.V., Shopova, A.V. Characteristics of Mononuclear Extracellular Traps in the Offspring of Female Rats with Drug-Induced Hepatitis. Bull Exp Biol Med 159, 435–437 (2015). https://doi.org/10.1007/s10517-015-2984-8

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  • DOI: https://doi.org/10.1007/s10517-015-2984-8

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