Using the cell model of regenerative cardiomyogenesis (formation of contracting cardiomyocyte colonies from resident stem cells), we found that the addition of cardiomyocyte-derived apoptotic bodies to the culture of neonatal myocardial cells stimulated proliferation and differentiation of cardiomyocyte precursors and the frequency of their contraction was 1.5-fold higher than in the control. Systemic administration of cardiomyocyte-derived apoptotic bodies to Wistar rats with chronic postinfarction heart failure during the early period of myocardial remodeling considerably improved the contractile function of the heart.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 25–28, January, 2015
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Tyukavin, A.I., Belostotskaya, G.B., Golovanova, T.A. et al. Stimulation of Proliferation and Differentiation of Rat Resident Myocardial Cells with Apoptotic Bodies of Cardiomyocytes. Bull Exp Biol Med 159, 138–141 (2015). https://doi.org/10.1007/s10517-015-2909-6
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DOI: https://doi.org/10.1007/s10517-015-2909-6