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Antioxidant Defense System after Single and Chronic Administration of Obestatin and Its Fragment (1-4) to Normal and Overweight Male Rats

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effects of anorectic peptide obestatin and its fragment (1-4) on the antioxidant defense system in animals with normal and experimentally induced increased body weight. In rats with normal body weight, no changes in activity of the antioxidant defense system 1 week after single administration of the substances. After chronic administration of obestatin and fragment (1-4) for 1 week, total antioxidant capacity of the plasma decreased; obestatin also lowered the content of TBA-reactive products. In the overweight rats, SOD-like activity in the plasma increased 1 week after chronic administration of obestatin. Hence, obestatin and its fragment (1-4) induced changes in the antioxidant defense system only after chronic administration.

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Authors and Affiliations

  1. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia

    E. E. Khirazova, E. S. Motorykina, A. A. Devyatov, M. V. Maslova, A. V. Graf, N. A. Sokolova, M. G. Golubeva & A. A. Kamenskii

  2. Department of Biophysics, Biological Faculty, M. V. Lomonosov State Moscow University, Moscow, Russia

    A. A. Bayzhumanov

Authors
  1. E. E. Khirazova
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  2. A. A. Bayzhumanov
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  3. E. S. Motorykina
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  4. A. A. Devyatov
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  5. M. V. Maslova
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  6. A. V. Graf
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  7. N. A. Sokolova
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  8. M. G. Golubeva
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  9. A. A. Kamenskii
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Corresponding author

Correspondence to E. E. Khirazova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 1, pp. 46-48, January, 2015 Original article submitted February 27, 2014

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Khirazova, E.E., Bayzhumanov, A.A., Motorykina, E.S. et al. Antioxidant Defense System after Single and Chronic Administration of Obestatin and Its Fragment (1-4) to Normal and Overweight Male Rats. Bull Exp Biol Med 159, 38–40 (2015). https://doi.org/10.1007/s10517-015-2884-y

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  • DOI: https://doi.org/10.1007/s10517-015-2884-y

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