Pretreatment with mGluR1 antagonist AIDA (1 mg/kg) nearly completely prevented the onset of tonic-clonic seizures and increased generation of NO in the cerebral cortex of rats with genetically determined audiogenic reaction to acoustic stimulation. Administration of mGluR5 antagonist MPEP (10 mg/kg) before audiogenic exposure was followed by a significant decrease in the degree of seizure and partially prevented increased generation of NO due to acoustic stimulation. These data indicate that mGlu receptors and NO play an important role in the pathogenetic mechanisms of audiogenic seizures.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
V. G. Bashkatova, B. Meldrum, A. Chapman, et al., Neirokhimiya, 18, No. 4, 258-261 (2001).
N. Ya. Lukomskaya, S. I. Vataev, E. P. Zhabko, and L. G. Magazanik, Ross. Fiziol. Zh., 98, No. 4, 449-460 (2012).
V. D. Mikoyan, L. N. Kubrina, and A. F. Vanin, Biofizika, 39, No. 5, 915-918 (1994).
M. Banach, B. Piskorska, S. J. Czuczwar, and K. K. Borowicz, CNS Neurol. Disord. Drug Targets, 10, No. 7, 808-819 (2011).
V. G. Bashkatova, V. D. Mikoyan, L. A. Malikova, and K. S. Raevskii, Bull. Exp. Biol. Med., 136, No. 1, 7-10 (2003).
V. G. Bashkatova and S. K. Sudakov, Bull. Exp. Biol. Med., 153, No. 5, 655-657 (2012).
A. J. Hobbs, A. Higgs, and S. Moncada, Annu. Rev. Pharmacol. Toxicol., 39, 191-220 (1999).
C. R. Jesse, L. Savegnago, J. B. Rocha, and C. W. Nogueira, Brain Res., 1198, 197-203 (2008).
A. Kłodzińska, E. Tatarczyńska, K. Stachowicz, and E. Chojnacka-Wójcik, J. Physiol. Pharmacol., 55, No. 1, Pt. 1, 113-126 (2004).
C. Moncada, D. Lekieffre, B. Arvin, and B. Meldrum, Neuroreport, 3, No. 6, 530-532 (1992).
R. Y. Nagaraja, G. Grecksch, K.G. Reymann, et al., Naunyn Schmiedebergs Arch. Pharmacol., 370, No. 1, 26-34 (2004).
F. Nicoletti, J. Bockaert, G. L. Collingridge, et al., Neuropharmacology, 60, Nos. 7-8, 1017-1041 (2011).
J. P. Pin and F. Acher, Curr. Drug Targets CNS Neurol. Disord., 1, No. 3, 297-317 (2002).
E. Sattarinezhad, H. Shafaroodi, K. Sheikhnouri, et al., Epilepsy Behav., 37, 36-42 (2014).
B. Schulz, M. Fendt, F. Gasparini, et al., Neuropharmacology, 41, No. 1, 1-7 (2001).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 1, pp. 4-6, January, 2015
Rights and permissions
About this article
Cite this article
Bashkatova, V.G., Sudakov, S.K. & Prast, H. Antagonists of Metabotropic Glutamate Receptors Prevent the Development of Audiogenic Seizures. Bull Exp Biol Med 159, 1–3 (2015). https://doi.org/10.1007/s10517-015-2874-0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-015-2874-0