The cardioprotective effects of Ganoderma lucidum extract were examined in experiments with global ischemia (45 min) and reperfusion (30 min) of isolated and perfused rat heart. The course of preventive administration of the extract in a dose of 400 mg/kg for 15 days diminished necrotic death of cardiomyocytes and reduced reperfusion contracture. Ganoderma lucidum extract demonstrated antioxidant properties. The authors believe that the cardioprotective properties of Ganoderma lucidum extract are largely determined by its antioxidant properties.
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References
S. A. Afanas’ev, A. V. Krylatov, T. V. Lasukova, and Yu. B. Lishmanov, Biokhimiya, 61, No. 10, 1779-1784 (1996).
S. A. Afanas’ev, T. V. Lasukova, and A. M. Chernyavskii, Bull. Exp. Biol. Med., 124, No. 6, 1217-1219 (1997).
T. V. Lasukova, E. V. Uskina, S. A. Afanas’ev, et al., Eksp. Klin. Farmakol., 60, No. 5, 51-53 (1997).
P. F. Litvitskii, Patol. Fiziol. Eksp. Ter., No. 2, 2-12 (2002).
L. N. Maslov and Yu. N. Konkovskaya, Eksp. Klin. Farmakol., 72, No. 4, 52-60 (2009).
L. N. Maslov, Yu. B. Lishmanov, A. G. Arbuzov, et al., Bull. Exp. Biol. Med., 147, No. 3, 331-334 (2009).
E. B. Men’shchikova, V. Z. Lankin, N. K. Zenkov, et al., Oxidative Stress: Prooxidants and Antioxidants [in Russian], Moscow (2006).
A. S. Syrkin, Myocardial Infarction [in Russian], Moscow (2003).
F. Martinello, S. M. Soares, J. J. Franco, et al., Food Chem. Toxicol., 44, No. 6, 810-818 (2006).
D. Sliva, Mini Rev. Med. Chem., 4, No. 8, 873-879 (2004).
A. T. Turer and J. A. Hill, Am. J. Cardiol., 106, No. 3, 360-368 (2010).
K. L. Wong, H. H. Chao, P. Chan, et al., Phytother. Res., 18, No. 12, 1024-1026 (2004).
Y. H. You and Z. B. Lin, Yao Xue Xue Bao, 38, No. 2, 85-88 (2003).
H. B. Zhao, S. Q. Lin, J. H. Liu, and Z. B. Lin, J. Pharmacol., 95, No. 2, 294-298 (2004).
M. Zhu, Q. Chang, L. K. Wong, et al., Phytother. Res., 13, No. 6, 529-531 (1999).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 12, pp. 700-703, December, 2014
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Lasukova, T.V., Maslov, L.N., Arbuzov, A.G. et al. Cardioprotective Activity of Ganoderma lucidum Extract during Total Ischemia and Reperfusion of Isolated Heart. Bull Exp Biol Med 158, 739–741 (2015). https://doi.org/10.1007/s10517-015-2851-7
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DOI: https://doi.org/10.1007/s10517-015-2851-7