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Effect of Heat Shock Protein 90 (Hsp90) on Migration and Invasion of Human Cancer Cells in Vitro

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of purifi ed native heat shock protein 90 (Hsp90) from bovine and mouse brain on migration and invasion of human glioblastoma (A-172) and fi brosarcoma (HT1080) cells. Hsp90 in concentrations of 0.01-0.10 mg/ml stimulated migration and invasion of tumor cells in vitro by 20-32% (p<0.05). Polyclonal antibodies to Hsp90 blocked the Hsp90-dependent stimulation of cell invasion, which indicates specifi city of the stimulating effect of extracellular Hsp90 on tumor cell invasion. Hence, extracellular Hsp90 can be considered as a promising molecular target, because its inhibition can suppress invasion and metastasizing of tumor cells.

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Authors and Affiliations

  1. Institute of Cell Biophysics of Russian Academy of Sciences, Pushchino, Russia

    A. V. Snigireva, V. V. Vrublevskaya, Yu. Yu. Skarga, Yu. V. Evdokimovskaya & O. S. Morenkov

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  1. A. V. Snigireva
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  2. V. V. Vrublevskaya
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  3. Yu. Yu. Skarga
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  4. Yu. V. Evdokimovskaya
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  5. O. S. Morenkov
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Correspondence to A. V. Snigireva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 4, pp. 475-478, April, 2014

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Snigireva, A.V., Vrublevskaya, V.V., Skarga, Y.Y. et al. Effect of Heat Shock Protein 90 (Hsp90) on Migration and Invasion of Human Cancer Cells in Vitro . Bull Exp Biol Med 157, 476–478 (2014). https://doi.org/10.1007/s10517-014-2595-9

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  • DOI: https://doi.org/10.1007/s10517-014-2595-9

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