Increased content of CD4+CD161+IL-17A+ Th17 lymphocytes in the peripheral blood was found in patients with pulmonary tuberculosis irrespective of the clinical form (infiltrative, disseminated) and variant of the disease (drug-sensitive, drug-resistant). The elevated content of Th17 cells in pulmonary tuberculosis is associated with hypersecretion of Th17-associated cytokines IL-17A and IL-22 in vitro that was most pronounced (in case of IL-17A) in patients with disseminated pulmonary tuberculosis.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 12, pp. 701-704, December, 2013
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Kononova, T.E., Urazova, O.I., Novitskii, V.V. et al. Functional Activity of Th-17 Lymphocytes in Pulmonary Tuberculosis. Bull Exp Biol Med 156, 743–745 (2014). https://doi.org/10.1007/s10517-014-2438-8
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DOI: https://doi.org/10.1007/s10517-014-2438-8